Yeungnam Univ J Med.  2008 Dec;25(2):128-133.

A Case of Pancreatic Acinar Cell Carcinoma

Affiliations
  • 1Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea.
  • 2Department of Surgery, Daegu Fatima Hospital, Daegu, Korea.
  • 3Department of Pathology, Daegu Fatima Hospital, Daegu, Korea.
  • 4Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. lkhee@med.yu.ac.kr

Abstract

Acinar cell carcinoma is a rare tumor that represents 1~2% of all pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease. Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-old man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased 18F-fluorodeoxyglucose (FDG) uptake. Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the pancreas. The patient underwent a total gastrectomy three months later because of gastric recurrence. Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy. During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabine.

Keyword

Pancreas; Carcinoma; Acinar Cell; Capecitabine

MeSH Terms

Abdominal Pain
Acinar Cells
Adult
Carcinoma, Acinar Cell
Deoxycytidine
Electrons
Fluorouracil
Gastrectomy
Hepatectomy
Humans
Neoplasm Metastasis
Pancreas
Pancreatectomy
Pancreatic Neoplasms
Recurrence
Splenectomy
Capecitabine
Deoxycytidine
Fluorouracil
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