Tuberc Respir Dis.  2009 Nov;67(5):462-466.

A Case of Malignant Rhabdoid Tumor in the Anterior Mediastinum

• Oh KJ
• Lee KB
• Hong SW
• Jung KT
• Choi HK
• Kim HJ
• Ahn CM
• Chang YS

Abstract

Malignant rhabdoid tumors arise primarily from the kidney. Extrarenal malignant rhabdoid tumors are rare, with the liver, central nervous system, and skin reported as the primary sites. Malignant rhabdoid tumors of the mediastinum are extremely rare among extrarenal malignant rhadoid tumors; only 3 cases have been reported to date, all characterized by aggressive clinical behavior. We experienced a 35-year-old woman diagnosed with malignant rhabdoid tumor in the anterior mediastinum with multiple metastases. The tumor was surgically unresectable, and treated with palliative radiation therapy. Three-month after radiation treatment, she died from dissemination of the malignant rabdoid tumor.

Keyword

Rhabdoid Tumor; Mediastinum

MeSH Terms

Adult
Central Nervous System
Female
Humans
Kidney
Liver
Mediastinum
Neoplasm Metastasis
Rhabdoid Tumor
Skin

Figure

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  Figure 1 Chest X-ray suggests huge mass lesion on left upper lung fileds (A, B).

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  Figure 2 Chest computed tomography shows 8.5 cm sized anterior mediastinal mass with contrast window (A), with lung window (B).

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  Figure 3 Whole body bone scan suggests metastasis to left lower posterior ribs (A), and PET-CT shows multiple metastasis to lymph node, both adrenal glands (B).

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  Figure 4 Histopathologic findings shows round tumor cells infiltrating surrounding tissues with eosinophilic cytoplasm containing amorphous inclusion body (H&E stain; A, ×40, B, ×400), positive staining in cytoplasm (Immunohistochemical staining; C, cytokeratin, ×400, D, vimentin, ×400).

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