Tuberc Respir Dis.  2009 Apr;66(4):295-299.

Incidence of Immunoglobulin G Subclass Deficiencies in Patients with Bronchiectasis and the Clinical Characteristics of Patients with Immunoglobulin G Subclass Deficiency and Bronchiectasis

• Kim CH
• Kim DG
• Park SH
• Choi JH
• Lee CY
• Hwang YI
• Shin TR
• Park SM
• Park YB
• Lee JY
• Jang SH
• Kim CH
• Mo EK
• Lee MG
• Hyun IG
• Jung KS

Abstract

BACKGROUND
There are various etiologies causing bronchiectasis, but the cases without definite causes account for a quite high proportion. It is also uncertain that immunoglobulin G subclass deficiency (IgGSD) is associated with bronchiectasis. Therefore, we tried to measure the frequency of IgGSD in patients with bronchiectasis of unclear etiology, and to observe the clinical features of those patients with bronchiectasis and IgGSD.
METHODS
For the outpatients of a university hospital who were diagnosed as bronchiectasis by chest CT, we produced comprehensive history taking and physical examinations, and finally selected 31 patients with bronchiectasis of unclear etiology.
RESULTS
Two patients had total immunoglobulin G deficiency. The frequency of IgGSD was comparatively high (n=14). When we compared IgGSD group to normal immunoglobulin G subclass group, there were no significant differences in sex, age, and the frequency of sinusitis, bronchial asthma, and the abnormal lung function.
CONCLUSION
In cases of bronchiectasis without definite causes, it can be considered to measure the level of immunoglobulin G subclass. It is also probably worthwhile to further evaluate the relationship between IgGSD and bronchiectasis.

Keyword

Bronchiectasis; Etiology; Immunoglobulins

MeSH Terms

Asthma
Bronchiectasis
Humans
Immunoglobulin G
Immunoglobulins
Incidence
Lung
Outpatients
Physical Examination
Sinusitis
Thorax
Immunoglobulin G
Immunoglobulins

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