Tuberc Respir Dis.  2006 Jul;61(1):41-45.

Difference in Protein Markers According to the Survival of Sepsis Patients using Protein Chips

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Kangwon National University, Korea. pulmo2@knuh.or.kr
  • 2Department of Anesthesia, College of Medicine, Kangwon National University, Korea.
  • 3Department of Molecular and Cellular Biochemistry, College of Medicine, Kangwon National University, Korea.

Abstract

BACKGROUND: Several clinical scoring systems are currently being used to predict the outcome of sepsis, but they all have certain limitations. Therefore, we sought to identify the proteomic biomarkers, with wsing proteomic tools, that differed according to the outcome of sepsis patients.
METHODS
Upon admission to the ICU, blood samples were obtained from the 16 patients with sepsis who were enrolled in this study. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) was used to identify the markers that could predict the outcome of sepsis.
RESULTS
We found six peaks, by using cation and anion chips, that statistically differed between those patients who died and those who survived.
CONCLUSION
The biomarkers we found by using proteomic tools may help predict the prognosis and also plan the treatment of sepsis.

Keyword

Sepsis; Treatment outcome; Proteomics

MeSH Terms

Biomarkers
Humans
Mass Spectrometry
Prognosis
Protein Array Analysis*
Proteomics
Sepsis*
Treatment Outcome
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