Tuberc Respir Dis.  2006 Mar;60(3):297-303.

The Correlation between the Radiological Changes and the Level of Transforming Growth Factor-beta1 in Patients with Pulmonary Tuberculosis

Affiliations
  • 1Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea. lydmd@hanmail.net

Abstract

BACKGROUND: Pulmonary tuberculosis is frequently accompanied with complications such as bronchiectasis, cavities, fibrosis and a deterioration of the lung function. However, there is little information available on the pathogenesis of these complications in pulmonary tuberculosis. Among the many factors involving in tissue remodeling, transforming growth factor-beta1 (TGF-beta1) is a potent stimulus of the extracellular matrix fomation and a mediator of potential relevance for airway wall remodeling. Therefore, this study examined the relationship between the radiological changes and the TGF-beta1 level in patients with pulmonary tuberculosis.
METHODS
Serum and bronchoalveolar lavage fluid (BALF) were collected from total of 35 patients before treating them for active pulmonary tuberculosis, and the TGF-beta1 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The BALF levels were recalculated as the epithelial lining fluid (ELF) levels using the albumin method. pulmonary function test (PFT) and high resolution computed tomography (HRCT) were performed before and after treatment.
RESULTS
There was a strong correlation between the serum TGF-beta1 level and the presence of cavities (r=0.404, p=0.006), even though the BAL TGF-beta1 level showed a weak correlation with complications. In addition, there was no correlation between the TGF-beta1 levels before treatment and the changes in the PFT and HRCT during treatment.
CONCLUSION
There is a correlation between the serum TGF-beta1 level and cavity formation in pulmonary tuberculosis before treatment. However, further study will be needed to confirm this.

Keyword

Pulmonary tuberculosis; TGF-beta1; Cavity; High resolution computed tomography

MeSH Terms

Bronchiectasis
Bronchoalveolar Lavage Fluid
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix
Fibrosis
Humans
Lung
Respiratory Function Tests
Transforming Growth Factor beta1
Tuberculosis, Pulmonary*
Transforming Growth Factor beta1

Figure

  • Figure 1 Correlation between TGF-β1 levels of serum and cavity score by HRCT


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