Tuberc Respir Dis.  2003 Sep;55(3):280-286.

Comparison with 99mTc MDP Bone Scintigraphy and Whole body 18FDG PET for the Evaluation of Bone metastases in Patients with Lung Cancer

• Chung JH
• Park MS
• Hahn CH
• Moon JW
• Kim YS
• Kim SK
• Chang J
• Lee JD
• Kim SK

Abstract

BACKGROUND: 99mTechnetium methylene diphosphonates(99mTc MDP) bone scintigraphy is current method of choice for the detection of bone metastases, but whole body 18F-fluoro-deoxy-D-glucose positron emission tomography(18FDG PET) offers superior spatial resolution and improved sensitivity. So we compared whole body 18FDG PET with 99mTc MDP bone scintigraphy in patients with skeletal metastases from lung cancer.
PATIENTS AND METHODS
Ninety-two patients with lung cancer taken 18FDG PET together with a 99mTc MDP bone scintigraphy within 1 month between March 2000 and March 2003 were investigated retrospectively.
RESULTS
The sensitivity, specificity and accuracy of the 99mTc MDP bone scintigraphy versus 18FDG PET for the detection of bone metastases in lung cancers were 59% vs 82%, 71% vs 94%, and 68% vs 91%, respectively. In the diagnosis of bone metastases from lung cancer, 18FDG PET was statistically superior to 99mTc MDP bone scintigraphy in its specificity and accuracy(P<0.0001).
CONCLUSIONS
Whole body 18FDG PET may be useful in detecting bone metastases among patients with lung cancer.

Keyword

18FDG PET; 99mTc MDP bone scintigraphy; Bone metastases; Lung cancer

MeSH Terms

Diagnosis
Electrons
Fluorodeoxyglucose F18*
Humans
Lung Neoplasms*
Lung*
Neoplasm Metastasis*
Radionuclide Imaging*
Retrospective Studies
Fluorodeoxyglucose F18