Toxicol Res.
2012 Sep;28(3):139-141.
A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring
- Affiliations
-
- 1College of Pharmacy, Dongduk Women's University, Seoul 136-714, Korea. kspark@dongduk.ac.kr
- 2National Institute of Environmental Research, Incheon 404-708, Korea.
- 3Korea Testing and Research Institute, Gimpo 415-871, Korea.
- 4University of Ulsan College of Medicine, Seoul 680-749, Korea.
Abstract
- Silver nanoparticles (size: 7.9 +/- 0.95 nm, dosage: 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of the pups. Silver level in the treated group was 132.4 +/- 43.9 ng/g in the kidney (12.3 fold compared to control group), 37.3 +/- 11.3 ng/g in the liver (7.9 fold), 42.0 +/- 8.6 ng/g in the lung (5.9 fold), and 31.1 +/- 4.3 ng/g in the brain (5.4 fold). This result suggested that the possible transfer of silver nanoparticles from pregnant dams to the fetus through mainly placenta.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Silver Nanoparticles as a Smart Antimicrobial Agent
- Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose
- Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
- Inhibition Effects of Silver Nanoparticles against Powdery Mildews on Cucumber and Pumpkin
- Application of Silver Nanoparticles for the Control of Colletotrichum Species In Vitro and Pepper Anthracnose Disease in Field
