Soonchunhyang Med Sci.  2014 Dec;20(2):184-187. 10.0000/sms.2014.20.2.184.

Involvement of the Bone Marrow by Dedifferentiated Liposarcoma: The First Case Report

Affiliations
  • 1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
  • 2Department of Pathology, Seoul National University Hospital, Seoul, Korea.
  • 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. mobitz@hanmail.net
  • 4Division of Hematology and Medical Oncology, Department of Internal Medicine, International St. Mary's Hospital, Incheon, Korea.

Abstract

We report on a first case of bone marrow metastasis by dedifferentiated liposarcoma. A 39-year-old male diagnosed with retroperitoneal dedifferentiated liposarcoma underwent surgery and postoperative radiotherapy. In spite of radiotherapy, his whole-body positron emission tomography showed high uptake in multiple bone metastasis. With thrombocytopenia, bone scan suggested bone marrow involvement. After bone marrow biopsy, bone marrow metastasis by dedifferentiated liposarcoma was finally confirmed. He was administered with systemic chemotherapy with doxorubicin. But he died 3 months after chemotherapy due to disease progression. This case revealed that in a patient of unexplained cytopenia with dedifferentiated liposarcoma, bone marrow metastasis should be in consideration.

Keyword

Liposarcoma; Bone marrow; Neoplasm metastasis; Doxorubicin

MeSH Terms

Adult
Biopsy
Bone Marrow*
Disease Progression
Doxorubicin
Drug Therapy
Humans
Liposarcoma*
Male
Neoplasm Metastasis
Positron-Emission Tomography
Radiotherapy
Thrombocytopenia
Doxorubicin
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