Radiat Oncol J.  2012 Sep;30(3):124-131.

Treatment outcome in patients with triple negative early stage breast cancers compared with other molecular subtypes

• Kim JY
• Chang SK
• Park H
• Lee BM
• Shin HS

Abstract

PURPOSE
To determine whether triple negative (TN) early stage breast cancers have poorer survival rates compared with other molecular types.
MATERIALS AND METHODS
Between August 2000 and July 2006, patients diagnosed with stage I, II early stage breast cancers, in whom all three markers (estrogen receptor, progesterone receptor, and human epidermal growth factor receptor [HER]-2) were available and treated with modified radical mastectomy or breast conserving surgery followed by radiotherapy, were retrospectively reviewed.
RESULTS
Of 446 patients, 94 (21.1%) were classified as TN, 57 (12.8%) as HER-2 type, and 295 (66.1%) as luminal. TN was more frequently associated with young patients younger than 35 years old (p = 0.002), higher histologic grade (p < 0.0001), and nuclear (p < 0.0001). The median follow-up period was 78 months (range, 4 to 130 months). There were 9 local relapses (2.0%), 15 nodal (3.4%), 40 distant metastases (9.0%), and 33 deaths (7.4%) for all patients. The rates of 5-year OS, DFS, LFS, and DMFS for all patients were 95.5%, 89.9%, 95.4%, and 91.7%, respectively. There were no significant differences in OS, DFS, LFS, and DMFS between triple negative and other subtypes (p > 0.05).
CONCLUSION
We found that patients with TN early stage breast cancers had no difference in survival rates compared with other molecular subtypes. Prospective study in homogeneous treatment group will need for a prognosis of TN early stage breast cancer.

Keyword

Triple negative breast cancer; Early stage; Overall survival; Disease-free survival; Locoregional relapse-free survival; Distant metastasis-free survival

MeSH Terms

Breast
Breast Neoplasms
Disease-Free Survival
Follow-Up Studies
Humans
Mastectomy, Modified Radical
Mastectomy, Segmental
Neoplasm Metastasis
Phenobarbital
Prognosis
Receptor, Epidermal Growth Factor
Receptors, Progesterone
Recurrence
Retrospective Studies
Survival Rate
Treatment Outcome
Phenobarbital
Receptor, Epidermal Growth Factor
Receptors, Progesterone