Psychiatry Investig.
2015 Jan;12(1):136-141. 10.4306/pi.2015.12.1.136.
Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorder
- Affiliations
-
- 1Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
- 2Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
- 3Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, Republic of Korea.
- 4Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea. yongku@korea.ac.kr
- KMID: 2316399
- DOI: http://doi.org/10.4306/pi.2015.12.1.136
Abstract
OBJECTIVE
The serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD).
METHODS
Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton's 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients.
RESULTS
Although not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes.
CONCLUSION
These results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.
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