Korean J Urol.  2013 Jul;54(7):486-489.

Prostate Metastasis of Malignant Melanoma

• Balaban M
• Selimoglu
• Horuz R
• Akca O
• Albayrak S

Abstract

Metastatic malignant melanoma of the prostate is extremely rare in clinical practice, and only one case has been reported in the English literature in the past 30 years. We report a case of malignant melanoma that metastasized to the prostate and review the current literature. A 50-year-old man with a history of malignant melanoma metastasis to the left axilla, which was excised 3 years ago, presented with lower urinary tract symptoms and gross hematuria. He underwent cystoscopy and transurethral resection of the prostate. The pathological examination showed metastatic malignant melanoma of the prostate gland. The patient died 6 months after the transurethral resection.

Keyword

Melanoma; Neoplasm metastasis; Prostate

MeSH Terms

Axilla
Cystoscopy
Hematuria
Humans
Lower Urinary Tract Symptoms
Melanoma
Neoplasm Metastasis
Prostate

Figure

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  FIG. 1 (A) Coronal and (B) sagittal magnetic resonance imaging images showing a 10 cm×4 cm×8 cm prostatic mass lesion that displaced the rectum posteriorly and the sigmoid colon laterally (arrow).

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  FIG. 2 Transurethral resection of the prostate and solid infiltration of malignant melanoma tissue (arrow).

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  FIG. 3 (A) Microscopic picture of metastatic malignant melanoma in the prostate (H&E, ×400). (B) Immunohistochemical stains for S-100 protein showed an intense diffuse positivity (×200). (C) Immunohistochemical stains for HMB-45 protein showed an intense diffuse positivity (×200). (D) Melanin A was also diffusely positive (×200).

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