Psychiatry Investig.
2009 Sep;6(3):222-225.
Genetic Polymorphisms in Dopamine- and Serotonin-Related Genes and Treatment Responses to Risperidone and Perospirone
- Affiliations
-
- 1Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Osaka, Japan. sniperwindsurfing@gmail.com
- 2Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
- 3Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan.
- 4Department of Psychiatry, Nara Medical University, Nara, Japan.
- 5Course of Letters, Kansai University, Osaka, Japan.
Abstract
- We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients.
MeSH Terms
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Genotype
Hand
Humans
Isoindoles
Polymorphism, Genetic
Real-Time Polymerase Chain Reaction
Receptors, Dopamine
Receptors, Dopamine D2
Receptors, Dopamine D4
Risperidone
Schizophrenia
Serotonin Plasma Membrane Transport Proteins
Tandem Repeat Sequences
Thiazoles
Isoindoles
Receptors, Dopamine
Receptors, Dopamine D2
Receptors, Dopamine D4
Risperidone
Serotonin Plasma Membrane Transport Proteins
Thiazoles
