Pediatr Gastroenterol Hepatol Nutr.  2014 Dec;17(4):209-213. 10.5223/pghn.2014.17.4.209.

Clonazepam Treatment of Pathologic Aerophagia in Children with Mental Retardation

• Lee GH
• Jang HJ
• Hwang JB

• KMID: 2315494
• DOI: http://doi.org/10.5223/pghn.2014.17.4.209

Abstract

PURPOSE
Pathologic aerophagia (PA) may lead to bowel perforation or volvulus in mentally retarded patients. The authors investigated the effects of clonazepam on the management of PA in children with severe to profound mental retardation (MR).
METHODS
This study was undertaken as a retrospective case analysis of 21 PA patients with MR who were followed for over 12 months and diagnosed as having PA. Patients were assigned to two management groups, that is, to a clonazepam randomized open-labeled, treatment group or a reassurance group. The following were recorded and analyzed; age, response, remission rate to clonazepam treatment, and the side effect of clonazepam. It was defined positive response (response+) as being symptom-free for a whole week within 1 month of commencing treatment and remission(+) as being symptom-free for a whole month within 6 months of treatment.
RESULTS
The average age of the 21 PA children with MR was 10 years and 13 patients were female. Symptom duration before diagnosis of PA was 7 months. Clinical features of the clonazepam-trial group (n=11) and the reassurance group (n=10) were non-significantly different. Response(+) was achieved by 2 patients (18.2%) in the clonazepam-trial group and by no patient in the reassurance group. Remission(+) was achieved by 6 patients (54.5%) in the clonazepam-trial group and by one patient (10%) in the reassurance group (p=0.040).
CONCLUSION
When PA children with MR with severe bowel distention are considered for surgical treatment to prevent acute abdomen, a trial of clonazepam could be recommended.

Keyword

Aerophagy; Child; Intellectual disability; Clonazepam

MeSH Terms

Abdomen, Acute
Aerophagy
Child*
Clonazepam*
Diagnosis
Female
Humans
Intellectual Disability*
Intestinal Volvulus
Mentally Disabled Persons
Retrospective Studies
Clonazepam

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