Korean J Urol.  2010 Nov;51(11):803-806.

Primary Classic Kaposi's Sarcoma of the Penis in an HIV-Negative Patient

Affiliations
  • 1Department of Urology, Seoul Veterans Hospital, Seoul, Korea. urodrljk@yahoo.co.kr
  • 2Department of Pathology, Seoul Veterans Hospital, Seoul, Korea.

Abstract

Kaposi's sarcoma (KS) is a multifocal hemorrhagic sarcoma that occurs primarily on the extremities. KS limited to the penis is rare and a well-recognized manifestation of acquired immune deficiency syndrome (AIDS). However, KS confined to the penis is extraordinary in human immunodeficiency virus (HIV)-negative patients. We present the case of a 68-year-old man with a dark reddish ulcerated nodule on the penile skin, which was reported as a nodular stage of KS. We detected no evidence of immunosuppression or AIDS or systemic involvements in further evaluations. In his past medical history, the patient had undergone three transurethral resections of bladder tumors due to urothelial cell carcinoma since 2000 and total gastrectomy, splenectomy, and adjuvant fluorouracil/cisplatin chemotherapy for 7 months due to advanced gastric carcinoma in 2005. The patient was circumcised and has had no recurrence for 2 years.

Keyword

HIV Seronegativity; Kaposi sarcoma; Penile neoplasms

MeSH Terms

Acquired Immunodeficiency Syndrome
Aged
Extremities
Gastrectomy
HIV
HIV Seronegativity
Humans
Immunosuppression
Male
Penile Neoplasms
Penis
Recurrence
Sarcoma
Sarcoma, Kaposi
Skin
Splenectomy
Ulcer
Urinary Bladder Neoplasms

Figure

  • FIG. 1 Histopathologic findings. (A) Ulcerated skin (black arrow) with nodule of spindle cells (yellow arrow) (H&E, ×100). (B) Spindle cell proliferation with intracytoplasmic lumina containing red cells (H&E, ×200). (C) Spindle cell proliferation with many mitoses (black arrow) (H&E, ×400). (D) The neoplastic cells are positive for the vascular marker, CD31 (×200). (E) The neoplastic cells are positive for the vascular marker, CD34 (×200). (F) The neoplastic cells are strongly positive for human herpesvirus type 8 latent nuclear antigen 1 (×200).


Reference

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