Nutr Res Pract.  2015 Apr;9(2):186-191. 10.4162/nrp.2015.9.2.186.

Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis: a double blind placebo controlled study

• Kolahi S
• Pourghassem Gargari B
• Mesgari Abbasi M
• Asghari Jafarabadi M
• Ghamarzad Shishavan N

• KMID: 2313828
• DOI: http://doi.org/10.4162/nrp.2015.9.2.186

Abstract

BACKGROUND/OBJECTIVES
Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease.
SUBJECTS/METHODS
Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention.
RESULTS
There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05).
CONCLUSIONS
Function of vitamin K1 in lipid profile modification remains still controversial. This study showed that vitamin K1 has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.

Keyword

Rheumatoid arthritis; vitamin K1; phylloquinone; lipid profile

MeSH Terms

Anxiety
Arthritis, Rheumatoid*
Cardiovascular Diseases
Cholesterol
Female
Humans
Lipoproteins
Mortality
Motor Activity
Triglycerides
Vitamin K
Vitamin K 1*
Cholesterol
Lipoproteins
Vitamin K
Vitamin K 1

Figure

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  Fig. 1 Flow chart of the study

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