Nutr Res Pract.  2013 Feb;7(1):22-25.

Effects of taurine on cadmium exposure in muscle, gill, and bone tissues of Carassius auratus

• Choi KS
• Yoo IS
• Shin KO
• Chung KH

Abstract

This study was performed in order to investigate the effects of taurine on cadmium poisoning in muscle, gill, and bone tissues of wild goldfish. For this experiment, 80 wild goldfish were divided into four experimental groups: 0.3 mg/L of cadmium and 0 mg/L of taurine (Group I), 0.3 mg/L of cadmium and 20 mg/kg of taurine (Group II), 0.3 mg/L of cadmium and 40 mg/L of taurine (Group III), and 0.3 mg/L of cadmium and 80 mg/L of taurine (Group IV). The results were as follows: The cadmium concentration in muscle tissue of wild goldfish was 0.65-3.21 mg/kg wet wt in Group I, whereas it decreased in Group IV. Levels of cadmium in gill tissue of wild goldfish were 16.57-42.39 mg/kg wet wt in Group I, 15.23-43.01 mg/kg wet wt in Group II, 15.11-39.56 mg/kg wet wt in Group III, and 13.15-38.55 mg/kg wet wt in Group IV (P < 0.05), suggesting that the cadmium concentration decreased in the experimental groups compared to control. The cadmium concentration in bone tissue of wild goldfish after 28 days was 0.52-9.75 mg/kg in Group II, whereas it increased in Group III (P < 0.05). In conclusion, taurine may have a preventive effect against cadmium accumulation in biological tissues.

Keyword

Cadmium; wild goldfish; muscle; gill; bone

MeSH Terms

Animals
Bone and Bones
Cadmium
Cadmium Poisoning
Gills
Goldfish
Muscles
Taurine
Cadmium
Taurine

Reference

1. Cherian MG, Nordberg M. Cellular adaptation in metal toxicology and metallothionein. Toxicology. 1983. 28:1–15.

2. Eaton DL, Toal BF. Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol. 1982. 66:134–142.

3. Kagi JH, Vallee BL. Metallothionein: a cadmium and zinc-containign protein from equine renal cortex. II. Physico-chemical properties. J Biol Chem. 1961. 236:2435–2442.

4. Kotsonis FN, Klaassen CD. Toxicity and distribution of cadmium administered to rats at sublethal doses. Toxicol Appl Pharmacol. 1977. 41:667–680.

5. Park TS. Taurine: its physiological roles and nutritional significance. Korean J Nutr. 2001. 34:597–607.

6. Ahn CS. Effects of taurine supplementation on serum lipidperoxide levels in middle-aged women. Korean J Food Nutr. 2007. 20:440–449.

7. Esquifino AI, Seara R, Fernández-Rey E, Lafuente A. Alternate cadmium exposure differentially affects the content of gamma-aminobutyric acid (GABA) and taurine within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats. Arch Toxicol. 2001. 75:127–133.

8. Hwang DF, Wang LC. Effect of taurine on toxicity of cadmium in rats. Toxicology. 2001. 167:173–180.

9. Kumar P, Prasad Y, Patra AK, Ranjan R, Swarup D, Patra RC, Pal S. Ascorbic acid, garlic extract and taurine alleviate cadmium-induced oxidative stress in freshwater catfish (Clarias batrachus). Sci Total Environ. 2009. 407:5024–5030.

10. Kim MK, Pak JY. Effect of dietary protein and cysteine levels on cadmium toxicity in rats. Korean J Nutr. 1996. 29:461–471.

11. Kim HY, Kim JC, Kim SY, Lee JH, Jang YM, Lee MS, Park JS, Lee KH. Monitoring of heavy metals in fishes in Korea. -As, Cd, Cu, Pb, Mn, Zn, Total Hg-. Korean J Food Sci Technol. 2007. 39:353–359.

12. Choi MS, Kinae N. Toxic effect of micropollutants on coastal organisms. I. Toxicity on some marine fishes. Bull Korean Fish Soc. 1994. 27:529–534.

13. Park T, Oh JY, Kim IS, Um YS. Changes of fatty acid compositions in hepatic total lipids and phospholipids of rats supplemented with cholesterol and taurine. J Korean Soc Food Sci Nutr. 1998. 27:1253–1261.

14. Kim SJ, Ha TY, Han CK, Kim NY, Ahn HS, Shin HK, Lim JK. Effects supplementation of folic acid, multiminerals, DHA on fertility rate of rats and growth and learning ability of their offsprings. Korean J Obstet Gynecol. 2002. 45:1588–1594.

15. Ahn CS, Lee YJ. Correlations of plasma taurine, homocysteine and serum lipid levels of elderly women. Korean J Food Nutr. 2010. 23:501–510.

16. Kang YS. The change on brain transport of choline and taurine by aging. J Pharm Sci. 2004. 20:37–41.

17. Kwon OR, Kim MK. The effect of dietary protein and calcium levels on the cadmium detoxication in rats. J Korean Home Econ Assoc. 1992. 30:99–113.

18. Shin MJ, Kwon OC, Lee JE, Seo EW. Effects of cadmium exposure on tissues of Carassius auratus. J Life Sci. 2010. 20:1490–1497.

19. Manna P, Sinha M, Sil PC. Amelioration of cadmium-induced cardiac impairment by taurine. Chem Biol Interact. 2008. 174:88–97.

20. Murakami S, Kondo Y, Toda Y, Kitajima H, Kameo K, Sakono M, Fukuda N. Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci. 2002. 70:2355–2366.

21. Manna P, Sinha M, Sil PC. Cadmium induced testicular pathophysiology: prophylactic role of taurine. Reprod Toxicol. 2008. 26:282–291.

22. Chung YH. The effect of dietary taurine on skeletal metabolism in ovariectomized rats. Korean J Hum Ecol. 2001. 4:84–93.

23. Sinha M, Manna P, Sil PC. Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine. J Trace Elem Med Biol. 2009. 23:300–313.