Nutr Res Pract.  2012 Dec;6(6):481-490.

Carotenoids and total phenolic contents in plant foods commonly consumed in Korea

• Yoon GA
• Yeum KJ
• Cho YS
• Chen CY
• Tang G
• Blumberg J
• Russell RM
• Yoon S
• Lee-Kim YC

Abstract

Phytochemicals are reported to provide various biological functions leading to the promotion of health as well as the reduced risk of chronic diseases. Fat-soluble plant pigments, carotenoids, are extensively studied micronutrient phytochemicals for their potential health benefits. It is noteworthy that specific carotenoids may be responsible for different protective effects against certain diseases. In addition, each carotenoid can be obtained from different types of plant foods. Considering the fact that the phytochemical content in foods can vary according to, but not limited to, the varieties and culture conditions, it is important to establish a database of phytochemicals in locally produced plant foods. Currently, information on individual carotenoid content in plant foods commonly consumed in Korea is lacking. As the first step to support the production and consumption of sustainable local plant foods, carotenoids and total phenolic contents of plant foods commonly consumed in Korea are presented and their potential biological functions are discussed in this review.

Keyword

Phytochemicals; carotenoids; total phenolics; plant foods in Korea

MeSH Terms

Carotenoids
Chronic Disease
Health Promotion
Insurance Benefits
Korea
Micronutrients
Phenol
Plants
Resin Cements
Carotenoids
Micronutrients
Phenol
Resin Cements

Figure

• 

  Fig. 1 β-Carotene contents in plant foods commonly consumed in Korea by family names. Umbelliferae (n = 10), Compositae (n = 10), Chenopodiaceae (n = 3), Liliaceae (n = 6), Cruciferae (n = 9), Cucurbitaceae (n = 6), Leguminosae (n = 7), Rosaceae (n = 9), Rutaceae (n = 3), Solanaceae (n = 8). Kruskal-Wallis one-way ANOVA on ranks with Dunn's test were performed to identify differences among median values. Different letters indicate significant differences (P < 0.05).

• 

  Fig. 2 Lutein contents in plant foods commonly consumed in Korea by family names. Umbelliferae (n = 10), Compositae (n = 10), Chenopodiaceae (n = 3), Liliaceae (n = 6), Cruciferae (n = 9), Cucurbitaceae (n = 6), Leguminosae (n = 7), Rosaceae (n = 9), Rutaceae (n = 3), Solanaceae (n = 8). Kruskal-Wallis one-way ANOVA on ranks with Dunn's test were performed to identify differences among median values. Different letters indicate significant differences (P < 0.05).

• 

  Fig. 3 Total phenolic contents in plant foods commonly consumed in Korea by family names. Umbelliferae (n = 10), Compositae (n = 10), Chenopodiaceae (n = 3), Liliaceae (n = 6), Cruciferae (n = 9), Cucurbitaceae (n = 6), Leguminosae (n = 7), Rosaceae (n = 9), Rutaceae (n = 3), Solanaceae (n = 8). Kruskal-Wallis one-way ANOVA on ranks with Dunn's test were performed to identify differences among median values. Different letters indicate significant differences (P < 0.05).

• 

  Fig. 4 Proposed functions of phytochemicals. Plant foods in parenthesis represent the major source of each phytochemical.

Reference

1. Vattem DA, Ghaedian R, Shetty K. Enhancing health benefits of berries through phenolic antioxidant enrichment: focus on cranberry. Asia Pac J Clin Nutr. 2005. 14:120–130.

2. Liu S, Manson JE, Lee IM, Cole SR, Hennekens CH, Willett WC, Buring JE. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr. 2000. 72:922–928.

3. Van Duyn MA, Pivonka E. Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. J Am Diet Assoc. 2000. 100:1511–1521.

4. Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr. 2003. 78:517S–520S.

5. Temple NJ. Antioxidants and disease: more questions than answers. Nutr Res. 2000. 20:449–459.

6. Willett WC. Balancing life-style and genomics research for disease prevention. Science. 2002. 296:695–698.

7. Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, Yannuzzi LA, Willett W. Eye Disease Case-Control Study Group. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA. 1994. 272:1413–1420.

8. Jacques PF, Chylack LT Jr, Hankinson SE, Khu PM, Rogers G, Friend J, Tung W, Wolfe JK, Padhye N, Willett WC, Taylor A. Long-term nutrient intake and early age-related nuclear lens opacities. Arch Ophthalmol. 2001. 119:1009–1019.

9. Hankinson SE, Stampfer MJ, Seddon JM, Colditz GA, Rosner B, Speizer FE, Willett WC. Nutrient intake and cataract extraction in women: a prospective study. BMJ. 1992. 305:335–339.

10. Hammond BR Jr, Curran-Celentano J, Judd S, Fuld K, Krinsky NI, Wooten BR, Snodderly DM. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Vision Res. 1996. 36:2001–2012.

11. Bone RA, Landrum JT, Mayne ST, Gomez CM, Tibor SE, Twaroska EE. Macular pigment in donor eyes with and without AMD: a case-control study. Invest Ophthalmol Vis Sci. 2001. 42:235–240.

12. Landrum JT, Bone RA. Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys. 2001. 385:28–40.

13. Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, Tete S, Madhappan B, Vecchiet J, De Lutiis MA, Caraffa A, Cerulli G. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006. 20:47–52.

14. Duthie SJ. Epigenetic modifications and human pathologies: cancer and CVD. Proc Nutr Soc. 2011. 70:47–56.

15. Palozza P, Catalano A, Simone R, Cittadini A. Lycopene as a guardian of redox signalling. Acta Biochim Pol. 2012. 59:21–25.

16. Lo HM, Tsai YJ, Du WY, Tsou CJ, Wu WB. A naturally occurring carotenoid, lutein, reduces PDGF and H(2)O(2) signaling and compromised migration in cultured vascular smooth muscle cells. J Biomed Sci. 2012. 19:18.

17. Mangels AR, Block G, Frey CM, Patterson BH, Taylor PR, Norkus EP, Levander OA. The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr. 1993. 123:1054–1061.

18. Holden JM, Eldridge AL, Beecher GR, Buzzard M, Bhagwat S, Davis CS, Douglass LW, Gebhardt S, Haytowitz D, Schakel S. Carotenoid content of U.S. foods: an update of the database. J Food Compost Anal. 1999. 12:169–196.

19. Cho YS, Park YH, Yoon S, Kim H, Lee-Kim YC, Yeum KJ, Tang G, Blumberg JB, Russell RM. Phytonutrient Contents in Vegetables/Fruits/Legumes. 2009. Seoul: Shinkwang Pub.

20. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture. USDA Database for the Proanthocyanidin Content of Selected Foods. 2004. Beltsville: U.S. Department of Agriculture, Agricultural Research Service.

21. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture. USDA Database for the Flavonoid Content of Selected Foods - Release 2.1. 2007. Beltsville: U.S. Department of Agriculture, Agricultural Research Service.

22. Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture. USDA Database for the Isoflavone Content of Selected Foods - Release 2.0. 2008. Beltsville: U.S. Department of Agriculture, Agricultural Research Service.

23. Pérez-Jiménez J, Neveu V, Vos F, Scalbert A. Systematic analysis of the content of 502 polyphenols in 452 foods and beverages: an application of the phenol-explorer database. J Agric Food Chem. 2010. 58:4959–4969.

24. Pérez-Jiménez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. Eur J Clin Nutr. 2010. 64:Suppl 3. S112–S120.

25. Neveu V, Perez-Jiménez J, Vos F, Crespy V, du Chaffaut L, Mennen L, Knox C, Eisner R, Cruz J, Wishart D, Scalbert A. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database (Oxford). 2010. 2010:bap024.

26. Arabbi PR, Genovese MI, Lajolo FM. Flavonoids in vegetable foods commonly consumed in Brazil and estimated ingestion by the Brazilian population. J Agric Food Chem. 2004. 52:1124–1131.

27. Correa CR, Li L, Aldini G, Carini M, Chen CY, Chun HK, Cho SM, Park KM, Russell RM, Blumberg JB, Yeum KJ. Composition and stability of phytochemicals in five varieties of black soybeans (Glycine max). Food Chem. 2010. 123:1176–1184.

28. Nisha P, Abdul Nazar P, Jayamurthy P. A comparative study on antioxidant activities of different varieties of Solanum melongena. Food Chem Toxicol. 2009. 47:2640–2644.

29. Lenucci MS, Cadinu D, Taurino M, Piro G, Dalessandro G. Antioxidant composition in cherry and high-pigment tomato cultivars. J Agric Food Chem. 2006. 54:2606–2613.

30. Li L, Aldini G, Carini M, Chen CY, Chun HK, Cho SM, Park KM, Correa CR, Russell RM, Blumberg JB, Yeum KJ. Characterisation, extraction efficiency, stability and antioxidant activity of phytonutrients in Angelica keiskei. Food Chem. 2009. 115:227–232.

31. Wang SY, Chen CT, Sciarappa W, Wang CY, Camp MJ. Fruit quality, antioxidant capacity, and flavonoid content of organically and conventionally grown blueberries. J Agric Food Chem. 2008. 56:5788–5794.

32. González R, Ballester I, López-Posadas R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F. Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr. 2011. 51:331–362.

33. Basu A, Du M, Sanchez K, Leyva MJ, Betts NM, Blevins S, Wu M, Aston CE, Lyons TJ. Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition. 2011. 27:206–213.

34. Gresele P, Cerletti C, Guglielmini G, Pignatelli P, de Gaetano G, Violi F. Effects of resveratrol and other wine polyphenols on vascular function: an update. J Nutr Biochem. 2011. 22:201–211.

35. Suri S, Liu XH, Rayment S, Hughes DA, Kroon PA, Needs PW, Taylor MA, Tribolo S, Wilson VG. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol. 2010. 159:566–575.

36. Fassett RG, Coombes JS. Astaxanthin: a potential therapeutic agent in cardiovascular disease. Mar Drugs. 2011. 9:447–465.

37. Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, Tsubono Y, Tsuji I. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA. 2006. 296:1255–1265.

38. Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, Hakulinen T, Aromaa A. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr. 2002. 76:560–568.

39. Sasazuki S, Kodama H, Yoshimasu K, Liu Y, Washio M, Tanaka K, Tokunaga S, Kono S, Arai H, Doi Y, Kawano T, Nakagaki O, Takada K, Koyanagi S, Hiyamuta K, Nii T, Shirai K, Ideishi M, Arakawa K, Mohri M, Takeshita A. Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Ann Epidemiol. 2000. 10:401–408.

40. Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2008. 88:38–50.

41. Mandel SA, Amit T, Weinreb O, Youdim MB. Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases. J Alzheimers Dis. 2011. 25:187–208.

42. Jia Z, Song Z, Zhao Y, Wang X, Liu P. Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-small ka, CyrillicB and MAPK protein expression. Mol Vis. 2011. 17:210–217.

43. Neuhouser ML. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer. 2004. 50:1–7.

44. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004. 74:2157–2184.

45. Li C, Ford ES, Zhao G, Balluz LS, Giles WH, Liu S. Serum alpha-carotene concentrations and risk of death among US Adults: the Third National Health and Nutrition Examination Survey Follow-up Study. Arch Intern Med. 2011. 171:507–515.

46. Liu S, Lee IM, Ajani U, Cole SR, Buring JE, Manson JE. Physicians' Health Study. Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: The Physicians' Health Study. Int J Epidemiol. 2001. 30:130–135.

47. Greenberg ER, Sporn MB. Antioxidant vitamins, cancer, and cardiovascular disease. N Engl J Med. 1996. 334:1189–1190.

48. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996. 334:1145–1149.

49. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994. 330:1029–1035.

50. Omenn GS, Goodman G, Thornquist M, Barnhart S, Balmes J, Cherniack M, Cullen M, Glass A, Keogh J, Liu D, Meyskens F Jr, Perloff M, Valanis B, Williams J Jr. Chemoprevention of lung cancer: the beta-Carotene and Retinol Efficacy Trial (CARET) in high-risk smokers and asbestos-exposed workers. IARC Sci Publ. 1996. 67–85.

51. Yeum KJ, Beretta G, Krinsky NI, Russell RM, Aldini G. Synergistic interactions of antioxidant nutrients in a biological model system. Nutrition. 2009. 25:839–846.

52. Doba T, Burton GW, Ingold KU. Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim Biophys Acta. 1985. 835:298–303.

53. Liebler DC, Kaysen KL, Burr JA. Peroxyl radical trapping and autoxidation reactions of alpha-tocopherol in lipid bilayers. Chem Res Toxicol. 1991. 4:89–93.

54. Mortensen A, Skibsted LH. Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. A real time kinetic study of antioxidant hierarchy. FEBS Lett. 1997. 417:261–266.

55. Palozza P, Krinsky NI. beta-Carotene and alpha-tocopherol are synergistic antioxidants. Arch Biochem Biophys. 1992. 297:184–187.

56. Aldini G, Yeum KJ, Carini M, Krinsky NI, Russell RM. (-)-Epigallocatechin-3-gallate prevents oxidative damage in both the aqueous and lipid compartments of human plasma. Biochem Biophys Res Commun. 2003. 302:409–414.

57. Bertipaglia de Santana M, Mandarino MG, Cardoso JR, Dichi I, Dichi JB, Camargo AE, Fabris BA, Rodrigues RJ, Fatel EC, Nixdorf SL, Simão AN, Cecchini R, Barbosa DS. Association between soy and green tea (Camellia sinensis) diminishes hypercholesterolemia and increases total plasma antioxidant potential in dyslipidemic subjects. Nutrition. 2008. 24:562–568.

58. Krinsky NI. The antioxidant and biological properties of the carotenoids. Ann N Y Acad Sci. 1998. 854:443–447.

59. Krinsky NI, Yeum KJ. Carotenoid-radical interactions. Biochem Biophys Res Commun. 2003. 305:754–760.

60. Palozza P, Krinsky NI. Antioxidant effects of carotenoids in vivo and in vitro: an overview. Methods Enzymol. 1992. 213:403–420.

61. Yeum KJ, Aldini G, Russell RM, Krinsky NI. Antioxidant/Pro-oxidant Actions of Carotenoids. 2009. Basel, Boston, Berlin: Birkhauser Verlag.

62. Rice-Evans CA, Sampson J, Bramley PM, Holloway DE. Why do we expect carotenoids to be antioxidants in vivo? Free Radic Res. 1997. 26:381–398.

63. Ziegler RG. Vegetables, fruits, and carotenoids and the risk of cancer. Am J Clin Nutr. 1991. 53:251S–259S.

64. Gaziano JM, Hennekens CH. The role of beta-carotene in the prevention of cardiovascular disease. Ann N Y Acad Sci. 1993. 691:148–155.

65. Riemersma RA, Wood DA, Macintyre CC, Elton RA, Gey KF, Oliver MF. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene. Lancet. 1991. 337:1–5.

66. Greenberg ER, Baron JA, Karagas MR, Stukel TA, Nierenberg DW, Stevens MM, Mandel JS, Haile RW. Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation. JAMA. 1996. 275:699–703.

67. Hercberg S, Kesse-Guyot E, Druesne-Pecollo N, Touvier M, Favier A, Latino-Martel P, Briançon S, Galan P. Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: a postintervention follow-up in the SU.VI.MAX Study. Int J Cancer. 2010. 127:1875–1881.

68. Kim J, Kim MK, Lee JK, Kim JH, Son SK, Song ES, Lee KB, Lee JP, Lee JM, Yun YM. Intakes of vitamin A, C, and E, and beta-carotene are associated with risk of cervical cancer: a case-control study in Korea. Nutr Cancer. 2010. 62:181–189.

69. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Cherniack MG, Brodkin CA, Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst. 1996. 88:1550–1559.

70. Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, Rautalahti M, Hartman AM, Palmgren J, Freedman LS, Haapakoski J, Barrett MJ, Pietinen P, Malila N, Tala E, Liippo K, Salomaa ER, Tangrea JA, Teppo L, Askin FB, Taskinen E, Erozan Y, Greenwald P, Huttunen JK. Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst. 1996. 88:1560–1570.

71. Druesne-Pecollo N, Latino-Martel P, Norat T, Barrandon E, Bertrais S, Galan P, Hercberg S. Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Int J Cancer. 2010. 127:172–184.

72. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988. 29:850–855.

73. Johnston CS, Taylor CA, Hampl JS. More Americans are eating "5 a day" but intakes of dark green and cruciferous vegetables remain low. J Nutr. 2000. 130:3063–3067.

74. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. 2000. Washington, D.C.: National Academies Press.

75. Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE, Comstock GW. Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol Biomarkers Prev. 1993. 2:335–339.

76. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr. cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev. 1996. 5:823–833.

77. Guil-Guerrero JL, Ramos-Bueno R, Rodríguez-García I, López-Sánchez C. Cytotoxicity screening of several tomato extracts. J Med Food. 2011. 14:40–45.

78. Micozzi MS, Beecher GR, Taylor PR, Khachik F. Carotenoid analyses of selected raw and cooked foods associated with a lower risk for cancer. J Natl Cancer Inst. 1990. 82:282–285.

79. Stahl W, Sies H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr. 1992. 122:2161–2166.

80. Yeum KJ, Booth SL, Sadowski JA, Liu C, Tang G, Krinsky NI, Russell RM. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. Am J Clin Nutr. 1996. 64:594–602.

81. Eberhardt MV, Lee CY, Liu RH. Antioxidant activity of fresh apples. Nature. 2000. 405:903–904.

82. Liu M, Li XQ, Weber C, Lee CY, Brown J, Liu RH. Antioxidant and antiproliferative activities of raspberries. J Agric Food Chem. 2002. 50:2926–2930.

83. de Kok TM, van Breda SG, Manson MM. Mechanisms of combined action of different chemopreventive dietary compounds: a review. Eur J Nutr. 2008. 47:Suppl 2. 51–59.

84. Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004. 134:3479S–3485S.

85. Somerset SM, Johannot L. Dietary flavonoid sources in Australian adults. Nutr Cancer. 2008. 60:442–449.

86. Lin LZ, Harnly JM. Identification of the phenolic components of collard greens, kale, and Chinese broccoli. J Agric Food Chem. 2009. 57:7401–7408.

87. Olsen H, Aaby K, Borge GI. Characterization and quantification of flavonoids and hydroxycinnamic acids in curly kale (Brassica oleracea L. Convar. acephala Var. sabellica) by HPLC-DAD-ESI-MSn. J Agric Food Chem. 2009. 57:2816–2825.

88. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 1993. 342:1007–1011.

89. Chen C, Tang HR, Sutcliffe LH, Belton PS. Green tea polyphenols react with 1,1-diphenyl-2-picrylhydrazyl free radicals in the bilayer of liposomes: direct evidence from electron spin resonance studies. J Agric Food Chem. 2000. 48:5710–5714.

90. Fuhrman B, Aviram M. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Opin Lipidol. 2001. 12:41–48.

91. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S, Pekkarinen M, Simic BS, Toshima H, Feskens EJ, Hollman PC, Katan MB. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med. 1995. 155:381–386.

92. Hodgson JM, Puddey IB, Croft KD, Burke V, Mori TA, Caccetta RA, Beilin LJ. Acute effects of ingestion of black and green tea on lipoprotein oxidation. Am J Clin Nutr. 2000. 71:1103–1107.

93. van het Hof KH, de Boer HS, Wiseman SA, Lien N, Westrate JA, Tijburg LB. Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr. 1997. 66:1125–1132.

94. Zamora-Ros R, Knaze V, Luján-Barroso L, Slimani N, Romieu I, Fedirko V, de Magistris MS, Ericson U, Amiano P, Trichopoulou A, Dilis V, Naska A, Engeset D, Skeie G, Cassidy A, Overvad K, Peeters PH, Huerta JM, Sánchez MJ, Quirós JR, Sacerdote C, Grioni S, Tumino R, Johansson G, Johansson I, Drake I, Crowe FL, Barricarte A, Kaaks R, Teucher B, Bueno-de-Mesquita HB, van Rossum CT, Norat T, Romaguera D, Vergnaud AC, Tjønneland A, Halkjær J, Clavel-Chapelon F, Boutron-Ruault MC, Touillaud M, Salvini S, Khaw KT, Wareham N, Boeing H, Förster J, Riboli E, González CA. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort. Br J Nutr. 2011. 106:1915–1925.

95. Yamada T, Hayasaka S, Shibata Y, Ojima T, Saegusa T, Gotoh T, Ishikawa S, Nakamura Y, Kayaba K. Jichi Medical School Cohort Study Group. Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study. J Epidemiol. 2011. 21:169–175.

96. Hollman PC, Feskens EJ, Katan MB. Tea flavonols in cardiovascular disease and cancer epidemiology. Proc Soc Exp Biol Med. 1999. 220:198–202.

97. World Health Organization. The World Health Report 2002 - Reducing Risks, Promoting Healthy Life. 2002. Geneva: World Health Organization.

98. World Health Organization. Fruit and Vegetable Promotion Initiatiative. A Meeting Report. 2003. 2003 Aug 25-27; Geneva: World Health Organization.

99. World Health Organization. Food and Agriculture Organization of the United Nations. Diet, Nutrition and the Prevention of Chronic Diseases: Report of a Joint WHO/FAO Expert Consultation. 2003. Geneva: World Health Organization.

100. Haytowitz DB, Lemar LE, Pehrsson PR, Exler J, Patterson KK, Thomas RG, Nickle MS, Williams JR, Showell BA, Khan M, Duvall M, Holden JM. USDA National Nutrient Database for Standard Reference, Release 24. 2011. Beltsville: U.S. Department of Agriculture, Agricultural Research Service.

101. Chu YF, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activities of common vegetables. J Agric Food Chem. 2002. 50:6910–6916.

102. Sun J, Chu YF, Wu X, Liu RH. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem. 2002. 50:7449–7454.