Nutr Res Pract.  2012 Jun;6(3):246-253.

The framingham risk score, diet, and inflammatory markers in Korean men with metabolic syndrome

• Sohn C
• Kim J
• Bae W

Abstract

The Framingham risk score (FRS) has been used to assess the risk of a cardiovascular event and to identify patients for risk factor modifications. Therefore, the purpose of this study was to evaluate the relationship of the FRS with dietary intake and inflammatory biomarkers. We conducted a cross-sectional study of 180 men (49.2 +/- 10.2 years) with MS. Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and adiponectin were examined. Participants were asked to complete the food frequency questionnaire (FFQ) using the previous 1 year as a reference point. The absolute cardiovascular disease (CVD) risk percentage over 10 years was calculated to estimate the FRS, which was classified as low risk (< 10%), intermediate risk (10-20%), and high risk (> 20%). Mean intake of polyunsaturated fatty acids was lower in subjects who had > 20% FRS than in subjects who had < 10% FRS (3.7 +/- 1.9 g/day vs. 4.7 +/- 1.9 g/day; P < 0.05). Significant differences in the Index of Nutritional Quality of protein, phosphorus, iron, vitamin A, vitamin B1, niacin, vitamin B6, and vitamin C were observed between the > 20% FRS group and the < 10% FRS group (P < 0.05). IL-6 concentrations were significantly lower in subjects with a < 10% FRS than in subjects who were 10-20% FRS or > 20% FRS (0.91 +/- 0.26 vs. 1.48 +/- 033 vs. 2.72 +/- 0.57 pg/mL, respectively; P < 0.05). IL-6 and dietary intake of polyunsaturated fatty acids together explained 6.6% of the variation in FRS levels in a stepwise multiple regression model. Our results provide some evidence that dietary intake in the higher CVD risk group was inferior to that in the lower risk group and that dietary fat intake and IL-6 were associated with FRS and MS in Korean men.

Keyword

Framingham risk score; inflammation; polyunsaturated fatty acid; antioxidant; metabolic syndrome

MeSH Terms

Adiponectin
Ascorbic Acid
Biomarkers
C-Reactive Protein
Cardiovascular Diseases
Cross-Sectional Studies
Diet
Dietary Fats
Fatty Acids, Unsaturated
Humans
Inflammation
Interleukin-6
Iron
Male
Niacin
Nutritive Value
Phosphorus
Surveys and Questionnaires
Risk Factors
Thiamine
Vitamin A
Vitamin B 6
Adiponectin
Ascorbic Acid
C-Reactive Protein
Dietary Fats
Fatty Acids, Unsaturated
Interleukin-6
Iron
Niacin
Phosphorus
Thiamine
Vitamin A
Vitamin B 6

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