Nucl Med Mol Imaging.
2016 Mar;50(1):70-75. 10.1007/s13139-015-0373-x.
Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [18F]FP-CIT PET Imaging Pilot Study
- Affiliations
-
- 1Department of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
- 2PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.
- 3Center for Research Information, Korea University, Seoul, Republic of Korea.
- 4Department of Neurology, Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.
- 5Department of Neurology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea. jungky10@gmail.com
- KMID: 2313277
- DOI: http://doi.org/10.1007/s13139-015-0373-x
Abstract
- PURPOSE
Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([18F]FP-CIT) positron emission tomography (PET).
METHODS
Brain [18F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BP(ND)) of [18F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters.
RESULTS
BP(ND) at the brainstem was significantly higher in adult migraineurs (n=6, 1.15±0.17) than healthy subjects (0.95±0.14) (p=0.04). Healthy subjects demonstrated negative correlation between brainstem BP(ND) and age (r=−0.64, p=0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP(ND) (r=0.66, p=0.02), when age and duration of illness were corrected.
CONCLUSIONS
Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [18F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.
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