Nucl Med Mol Imaging.  2009 Feb;43(1):35-39.

Diffuse Hypermetabolism at Bone Marrow in F-18 FDG PET/CT: Correlation with Bone Marrow Biopsy and Complete Blood Cell Counts

• Kang YH
• Lim ST
• Jeong YJ
• Kim DW
• Jeong HJ
• Sohn MH

Abstract

PURPOSE: Increased FDG uptake in the bone marrow has been reported in patients taking erythropoietin or granulocyte-colony stimulating factor (G-CSF). The aim of this study is to investigate the correlation between F-18 FDG uptake in the bone marrow and bone marrow finding, hematological parameters.
MATERIALS AND METHODS
Twenty patients who had diffuse FDG uptake at the bone marrow and received hematological examinations, bone marrow biopsy within 10 days before or after PET/CT were enrolled in this study. Among them, 11 patients were excluded; 4 patients received G-CSF or erythropoietin before PET/CT. Seven patients showed definite pathology in a bone marrow biopsy. The parameters included the measurement of WBC, hemoglobin, platelet and cellularity of the bone marrow.
RESULTS
Bone marrow FDG uptake was correlated with a low hemoglobin but not WBC, platelet. Histopathologic findings in marrow biopsies were various: normal finding (n=3), hyperplasia of granulocytic cells (n=2), eosinophilic hyperplasia (n=1), reactive lymphoid nodules (n=1), hypercelluar marrow (n=1), hypocelluar marrow (n=1). All patients except two, showed normal marrow celluarity.
CONCLUSION
FDG uptake by bone marrow correlated with anemia but not WBC, platelet, bone marrow cellularity.

Keyword

Bone marrow; PET/CT; bone marrow biopsy; complete blood cell counts; FDG

MeSH Terms

Anemia
Biopsy
Blood Cell Count
Blood Cells
Blood Platelets
Bone Marrow
Bone Marrow Examination
Eosinophils
Erythropoietin
Granulocyte Colony-Stimulating Factor
Hemoglobins
Humans
Hyperplasia
Erythropoietin
Granulocyte Colony-Stimulating Factor
Hemoglobins