Neonatal Med.  2014 Aug;21(3):166-171.

Comorbid Risk Factors of Persistent Pulmonary Hypertension of the Newborn in Infants with Meconium Aspiration Syndrome

Affiliations
  • 1Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. peddoc@paik.ac.kr

Abstract

PURPOSE
Persistent pulmonary hypertension (PPHN) is considered an important prognostic factor in meconium aspiration syndrome (MAS). The aim of this study was to determine the comorbid risk factors for PPHN in infants with MAS.
METHODS
We retrospectively analyzed 60 infants diagnosed with MAS and admitted to the neonatal intensive care unit of the Sanggye Paik Hospital from January 2007 to April 2013. There were 28 infants (47%) with PPHN and 32 infants (53%) without PPHN. Clinical characteristics, laboratory findings within 24 hours after birth, and initial capillary blood gas analysis results were compared between infants with and without PPHN.
RESULTS
Incidence of PPHN was associated with the severity of MAS (P<0.001). The PPHN group had a greater incidence of hypotension and hypoxic-ischemic encephalopathy within 24 hours of birth compared to the non-PPHN group. The PPHN group also had a lower initial pH. However, there was no significant difference for laboratory findings within 24 hours of birth and initial capillary blood gas analysis. In the multivariate analysis, hypotension within 24 hours of birth (P=0.046, odds ratio 11.494, 95% confidence interval 1.048-125.00) was found to be a significant comorbid factor for PPHN in infants with MAS.
CONCLUSION
Infants with MAS who develop hypotension within 24 hours of birth should be closely monitored for development of PPHN.

Keyword

Meconium aspiration syndrome; Persistent pulmonary hypertension of the newborn; Hypotension

MeSH Terms

Blood Gas Analysis
Capillaries
Humans
Hydrogen-Ion Concentration
Hypertension, Pulmonary*
Hypotension
Hypoxia-Ischemia, Brain
Incidence
Infant*
Infant, Newborn*
Intensive Care, Neonatal
Meconium Aspiration Syndrome*
Multivariate Analysis
Odds Ratio
Parturition
Retrospective Studies
Risk Factors*
Full Text Links
  • NM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr