Mycobiology.  2011 Jun;39(2):137-139.

Antihypertensive Angiotensin I-Converting Enzyme Inhibitory Activity and Antioxidant Activity of Vitis hybrid-Vitis coignetiae Red Wine Made with Saccharomyces cerevisiae

• Jang JH
• Lee JS

Abstract

A Vitis hybrid-Vitis coignetiae red wine was vinified by fermentation of a mixture of a Vitis hybrid-Vitis coignetiae must with Saccharomyces cerevisiae KCTC 7904 at 25degrees C for 10 days. The Vitis hybrid-Vitis coignetiae red wine showed high antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity (67.8%) and antioxidant activity (76.7%). The antihypertensive ACE inhibitor in the Vitis hybrid-Vitis coignetiae red wine was partially purified by solid phase extraction chromatography, and its ACE inhibitory activity yielded an IC50 of 1.8 mg/mL. Six kinds of oligopeptides, including five new kinds, were contained in the partially purified ACE inhibitor fraction from the red wine after 10 days of fermentation. Antioxidant activity decreased significantly from 76.7% to 40.5% when the post-fermentation period was prolonged to 30 days.

Keyword

Antihypertensive ACE inhibitory activity; Antioxidant activity; Vitis hybrid-Vitis coignetiae red wine

MeSH Terms

Angiotensins
Chromatography
Fermentation
Inhibitory Concentration 50
Oligopeptides
Peptidyl-Dipeptidase A
Saccharomyces
Saccharomyces cerevisiae
Solid Phase Extraction
Vitis
Wine
Angiotensins
Oligopeptides
Peptidyl-Dipeptidase A