Korean J Urol.  2008 Feb;49(2):168-173.

A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis

• Kim JM
• Kim YS
• Namgoong M
• Park KH
• Park YH
• Lee SD
• Lee SJ
• Chung JY
• The Korean Enuresis Association

Abstract

PURPOSE
We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis(NE). MATERIALS AND METHODS: The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1(imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2(desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data. RESULTS: Mean wetting events in group 1 decreased from 8.8 to 5.1 times(2 weeks) and 3.0 times(4 weeks)(p=0.009) versus 10.2 to 5.5 times(2 weeks) and 6.4 times(4 weeks)(p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9(baseline), 4.4(2 weeks), and 3.7(4 weeks), and, for group 2, 5.1(baseline), 4.8(2 weeks), and 4.8(4 weeks). The two groups were not different(p=0.14, p=0.73). CONCLUSIONS: Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability.

Keyword

Nocturnal enuresis; Arousal; Imipramine; Deamino arginine vasopressin

MeSH Terms

Arousal
Child
Deamino Arginine Vasopressin
Humans
Imipramine
Korea
Nocturnal Enuresis
Prospective Studies
Deamino Arginine Vasopressin
Imipramine

Figure

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  Fig. 1 Sleeping patterns of patients. (A) Duration of sleeping time, (B) Bed time, (C) Time to wake up.

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