J Dent Anesth Pain Med.  2015 Mar;15(1):1-4.

The alternative of oral sedation for pediatric dental care

• Kim J
• Kim S
• Lee DW
• Ryu DS

Abstract

In pediatric dentistry, chloral hydrate is habitually selected for sedation of uncooperative children. Although chloral hydrate has been used for decades, various adverse effects are reported and necessity for new alternative drugs has increased. Dexmedetomidine was approved by FDA for sedation at intensive care units (ICU) in 1999. Compared to conventional sedative drugs, dexmedetomidine has not only analgesic and sedative effects but also it barely suppresses the respiratory system. Due to these characteristics, dexmedetomidine is known as safe sedative drug for children and elderly patients. Furthermore, approved by KFDA in 2010 in Korea, the frequency of sedation using dexmedetomidine is increasing. However, due to its intravenous administration method, it was difficult to apply in pediatric dentistry. Recently, intranasal administration method was introduced which might be a new possible alternative of oral sedation. In this study, we compare the mechanisms, pros and cons of chloral hydrate and dexmedetomidine, introducing new possibilities.

Keyword

Chloral hydrate; Dexmedetomidine; Oral Sedation; Sedation

MeSH Terms

Administration, Intranasal
Administration, Intravenous
Aged
Child
Chloral Hydrate
Dental Care*
Dexmedetomidine
Humans
Hypnotics and Sedatives
Intensive Care Units
Korea
Methods
Pediatric Dentistry
Respiratory System
Chloral Hydrate
Dexmedetomidine
Hypnotics and Sedatives

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