Blood Res.  2016 Jun;51(2):144-147. 10.5045/br.2016.51.2.144.

A rare case of diffuse large B cell lymphoma-associated hemophagocytic syndrome initially present in the bone marrow with a favorable clinical course

• Park SH
• Lee EY
• Chung JS

• KMID: 2309220
• DOI: http://doi.org/10.5045/br.2016.51.2.144

Abstract

No abstract available.

MeSH Terms

Bone Marrow*
Lymphohistiocytosis, Hemophagocytic*

Figure

• 

  Fig. 1 Bone marrow aspirates (A, B, Wright stain, ×400) and touch print (C, D, Wright stain, ×400). The bone marrow aspirates and touch print show normocellular marrow with infiltration of neoplastic lymphoid cells (20.0% of total nucleated cells, orange arrows). In addition, hemophagocytic histiocytes (11.0% of total nucleated cells, yellow arrows) were identified.

• 

  Fig. 2 Bone marrow biopsy (A, hematoxylin and eosin stain, ×400) and immunohistiochemical staining results for CD3, CD20 and CD68 (B–D, ×400, respectively). The bone marrow biopsy shows normocellular marrow with diffuse infiltration of CD20-positive neoplastic lymphoid cells (orange arrows) accompanied by an increase of CD68-positive histiocytes with occasional hemophagocytosis (yellow arrows), indicating the presence of B-cell lymphoma associated with hemophagocytic histiocytosis.

Reference

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