Blood Res.  2016 Jun;51(2):133-137. 10.5045/br.2016.51.2.133.

Acute myeloid leukemia with t(4;12)(q12;p13): report of 2 cases

• Kim KH
• Kim MJ
• Ahn JY
• Park PW
• Seo YH
• Jeong JH

• KMID: 2309216
• DOI: http://doi.org/10.5045/br.2016.51.2.133

Abstract

No abstract available.

MeSH Terms

Leukemia, Myeloid, Acute*

Figure

• 

  Fig. 1 Case 1 (A) Bone marrow aspirates from patient 1. Large, round nucleus with a blocky chromatin pattern in agranular cytoplasm (Wright stain, ×1,000). (B) Karyotype of patient 1: 46,XY,t(4;12)(q12;p13),del(5)(q22q35)[20]. (C) FISH analysis using a Vysis LSI 4q12 tricolor probe showed cells with 1 tri-color fusion, 1 orange/green fusion, and 1 aqua signal (arrow). (D) FISH analysis using a Vysis LSI ETV6/RUNX1 ES probe showed 3 green and 2 orange signals in interphase and metaphase cells, revealing an ETV6 rearrangement [purple arrow: ETV6 signal on der(4)t(4;12), blue arrow: ETV6 signal on native chromosome 12, red arrow: ETV6 signal on der(12)t(4;12)].

• 

  Fig. 2 Case 2 (A) Bone marrow aspirates from patient 2. Large, round nucleus with a blocky chromatin pattern with a prominent nucleolus (red arrow). Basophil (blue arrow) (Wright stain, ×1,000). (B) Karyotype of patient 2: 46,XY,t(4;12)(q12;p13)[13]. (C) FISH analysis using an XL FIP1L1/CHIC2/PDGFRA probe showed 2 orange/green fusions and 1 green signal (arrow). (D) FISH analysis using a Vysis LSI ETV6/RUNX1 ES probe showed 3 green and 2 orange signals in interphase and metaphase cells, revealing an ETV6 rearrangement. (E) FISH analysis using an XL del(7)(q22q31) tri-color probe showed 2 aqua, 2 green, and 2 orange signals at the initial diagnosis. (F) FISH analysis using an XL del(7)(q22q31) tri-color probe showed 2 aqua, 1 green, and 1 orange signal at the follow-up, showing deletion signals for 7q22-7q31.

Reference

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