Lab Anim Res.  2016 Jun;32(2):128-132. 10.5625/lar.2016.32.2.128.

Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog

Affiliations
  • 1Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. vetmed2@snu.ac.kr
  • 2Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. snujang@snu.ac.kr
  • 3Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea.
  • 4Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea.
  • 5BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
  • 6Institute of Green Bio Science & Technology, Seoul National University, Pyeong Chang, Kangwon-do, Korea.
  • 7Emergence Center for Food-Medicine Personalized Therapy System, Advanced Institutes of Convergence Technology, Seoul National University, Gyeonggi-do, Korea.

Abstract

Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis. In the present study, we investigated the expression of estrogen and progesterone receptors in the normal and cryptorchid testis of a dog. Elective orchidectomy was performed on the dog's abdominal right testis (undescended, cryptorchid) and scrotal left testis (descended, normal). In the normal testis, estrogen receptor α immunoreactivity was detected in Leydig cells alone, while estrogen receptor α immunoreactivity in the cryptorchid testis was significantly prominent in the Sertoli cells as well. In addition, progesterone receptor immunoreactivity in the control testis was detected in the spermatids, but was not detected in the cryptorchid testis. This result suggests that unilateral cryptorchidism causes increases of estrogen receptor α expression in Sertoli cells.

Keyword

Dog; estrogen receptor α; progesterone receptor; Sertoli cells; unilateral cryptorchidism

MeSH Terms

Animals
Cryptorchidism
Dogs*
Estrogens*
Leydig Cells
Male
Orchiectomy
Progesterone*
Receptors, Progesterone*
Sertoli Cells
Spermatids
Spermatogenesis
Testis*
Estrogens
Progesterone
Receptors, Progesterone
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