Int J Arrhythm.  2016 Mar;17(1):32-35. 10.18501/arrhythmia.2016.004.

NOAC in Asian

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Abstract

Anticoagulation treatment, including novel or non-vitamin K-dependent antagonist oral anticoagulants (NOACs), is essential to prevent thromboembolic events in high-risk atrial fibrillation patients. There are not enough studies on the effect and safety of NOACs in Asians. Due to the low body surface area, genetic polymorphism, and herbal diet of Asians, it is difficult to attain optimal anticoagulation with traditional anticoagulation treatment using vitamin K antagonists, and more bleeding complications are reported with this treatment. In several recent studies, the use of NOACs in Asians resulted in lower thrombo- embolic events and fewer bleeding complications than those with a vitamin K antagonist. Given the race-related differences of Asians, NOACs have sufficient efficacy and safety for the prevention of thromboembolic events in patients with atrial fibrillation.

Keyword

Atrial Fibrillation; Anticoagulation; Stroke; Embolism

MeSH Terms

Anticoagulants
Asian Continental Ancestry Group*
Atrial Fibrillation
Body Surface Area
Diet
Embolism
Hemorrhage
Humans
Polymorphism, Genetic
Stroke
Vitamin K
Anticoagulants
Vitamin K
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