Korean J Urol Oncol.  2015 Dec;13(3):134-137. 10.0000/kjuo.2015.13.3.134.

Leukemoid Reaction, a Rare Paraneoplastic Syndrome in Urothelial Cell Carcinoma: Is It an Indicator of a Poor Prognosis?

• Chung HS
• Shin BS
• Yu HS
• Hwang EC
• Kim SO
• Jung SI
• Kang TW
• Kwon DD
• Park K

• KMID: 2307846
• DOI: http://doi.org/10.0000/kjuo.2015.13.3.134

Abstract

A leukemoid reaction is usually associated with malignancies of the lung, stomach, and thyroid. In contrast, urothelial cell carcinoma is rarely associated with leukemoid reactions, with few cases reported over the past 30 years. Here, we describe a patient with urothelial cell carcinoma who exhibited a leukemoid reaction. The patient had an elevated white blood cell count and experienced a rapid and aggressive clinical course, terminating in death. For urothelial cell carcinoma patients exhibiting a leukemoid reaction, removal of the inciting tumor is the definitive treatment. However, considering the aggressive nature of these tumors, if the patient is unsuitable for radical surgical management, palliative chemotherapy should be considered.

Keyword

Urothelial cell carcinoma; Leukemoid reaction; Prognosis; Chemotherapy

MeSH Terms

Drug Therapy
Humans
Leukemoid Reaction*
Leukocyte Count
Lung
Paraneoplastic Syndromes*
Prognosis*
Stomach
Thyroid Gland