Korean J Neurogastroenterol Motil.  2007 Dec;13(2):118-122.

Expression of p53 and Ki-67 Protein in Duodenogastric Reflux Gastritis after Subtotal Gastrectomy

• Choi SC
• Kim YS
• Kim KH
• Kim HS
• Yun KJ

Abstract

BACKGROUND/AIMS: Duodenogastric reflux of bile and other contents of duodenum is one of the main etiologic fators in chronic gastritis, and chronic inflammation has been recognized as a risk factor of human cancer. The aim of this study was therefore to evaluate the expression of p53 and Ki-67 protein in duodenogastric reflux gastritis.
METHODS
To evaluate the proliferation activity and tumor suppressor gene expression, 16 cases of duodenogastric reflux gastritis and 16 cases of control gastric tissue after subtotal gastrectomy were examined immunohistochemically using the monoclonal antibodies to Ki-67 and p53 protein.
RESULTS
The mean duration of follow-up endoscopic biopsy after subtotal gastrectomy was 607 days in duodenogastric reflux gastritis and 556 days in control groups. The mean intensity of Ki-67 in duodenogastric reflux gastritis was significantly higher than that of control tissues (3.0 vs 2.0). The mean intensity of p53 protein in duodenogastric reflux gastritis was significantly higher than that of control tissues (2.0 vs 1.0).
CONCLUSIONS
The high expressions of Ki-67 and p53 protein in duodenogastric reflux gastritis may be one of the main mechanisms in the development of gastric stump carcinoma.

Keyword

Duodenogastric reflux gastritis after subtotal gastrectomy; Ki-67; p53; Gastric stump carcinoma

MeSH Terms

Antibodies, Monoclonal
Bile
Biopsy
Duodenogastric Reflux*
Duodenum
Follow-Up Studies
Gastrectomy*
Gastric Stump
Gastritis*
Genes, Tumor Suppressor
Humans
Inflammation
Risk Factors
Antibodies, Monoclonal