Korean J Infect Dis.  2001 Apr;33(2):153-156.

A Case of Lumbar Vertebral Osteomyelitis Caused by Aspergillus fumigatus

• Heo ST
• Jung SI
• Kim YS
• Woo WS
• Cho HL
• Kim S
• Peck KR
• Song JH
• Lee NY

Abstract

Aspergillus fumigatus is the most common pathogen causing invasive aspergillosis. Although invasive aspergillosis mainly involves lung, brain, and sinus, Aspergillus fumigatus osteomyelitis of the spine has been reported very rarely. We experienced a case of vertebral Aspergillus osteomyelitis and report it with a review. A 70-year-old women was admitted due to progressive lower back pain, which had begun 1 month before admission. Although she had diabetes and hypertension, no other underlying disease or immune dysfunction was found. MRI of spine showed severely destroyeded lumbar spines. Debridement and bone graft was done for correction of unstable spine, and Aspergillus fumigatus was grown from surgical specimen. Amphotericin B was given up to total 2 g, and was switched to oral itraconazole maintenance therapy. She is well until now, 120 days after operation. On the other hand, anthracofibrosis due to Mycobacterium tuberculosis was found through bronchoscopic study, which was done because of atelectasis in left lower lobe of lung. Therefore she was treated with anti-tuberculous agents also.

Keyword

Aspergillus fumigatus; Osteomyelitis; Invasive aspergillosis; Amphotercin B; Itraconazole

MeSH Terms

Aged
Amphotericin B
Aspergillosis
Aspergillus fumigatus*
Aspergillus*
Brain
Debridement
Female
Hand
Humans
Hypertension
Itraconazole
Low Back Pain
Lung
Magnetic Resonance Imaging
Mycobacterium tuberculosis
Osteomyelitis*
Pulmonary Atelectasis
Spine
Transplants
Amphotericin B
Itraconazole