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Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

Won EJ, Joo MY, Lee D, Kim MN, Park YJ, Kim SH, Shin MG, Shin JH

We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates...
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Aspergillus Laryngotracheobronchitis in a Child with Primary Immunodeficiency

Moon SY, Lee S, Kim YS, Park JD, Choi YH

Laryngotracheobronchitis (LTB) is a common disease in the pediatric population, and it is rarely caused by a fungal infection. Acute respiratory failure caused by fungal LTB mainly occurs in immunocompromised...
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Development of Aspergillus fumigatus-induced chronic atopic dermatitis mouse model

Park A, Park H, Yu J

PURPOSE: Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease with skin barrier defects and altered immune responses. Chronic inflammation leads to irreversible fibrosis in the...
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Fungal Allergen Propensity Study Confirmed Through Multiple Allergosorbent Chemiluminescent Assay

Choi Y, Park J

BACKGROUND: Exposure and sensitization to fungal allergens can evoke the development and worsen allergic diseases. Many patients with allergies show multiple positive reactions to different allergens. OBJECTIVE: The purpose of this...
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Aspergillus fumigatus infection in an ostrich with an enlarged neck due to respiratory problems

This study describes a sudden death in an ostrich (Struthio camelus) with a big neck. Grossly, the air sacs were thickened. Yellow to white, round or coalescent material was scattered...
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Allergic bronchopulmonary mycosis – pathophysiology, histology, diagnosis, and treatment

Asano K, Kamei K, Hebisawa A

Allergic bronchopulmonary mycosis (ABPM) develops mainly in patients with asthma or cystic fibrosis via types I and III hypersensitivity reactions to filamentous fungi. Aspergillus spp., especially Aspergillus fumigatus, is the...
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A Case of Fungal Ball Causing Acute Dacryocystitis

Hwang YS, Yang HJ, Paik JS, Yang SW

PURPOSE: We report a case of fungal ball after Endoscopic Dacryocystorhinostomy (DCR) in a 40-year-old female patient. CASE SUMMARY: A 40-year-old female patient was admitted to our hospital for left lower...
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Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics

Ghebre MA, Desai D, Singapuri , Woods J, Rapley L, Cohen S, Herath A, Wardlaw AJ, Pashley CH, May R, Brightling CE

Aspergillus fumigatus sensitization and culture in asthma are associated with disease severity and lung function impairment, but their relationship with airway inflammation is poorly understood. We investigated the profile of...
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Drosophila melanogaster as a Model for Studying Aspergillus fumigatus

AL-Maliki , Martinez S, Piszczatowski P, Bennett JW

Drosophila melanogaster is a useful model organism that offers essential insights into developmental and cellular processes shared with humans, which has been adapted for large scale analysis of medically important...
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In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus

Seo YH, Kim SS, Shin KS

2',4'-Dihydroxychalcone (2',4'-DHC) was identified from a heat shock protein 90 (Hsp90)-targeting library as a compound with Hsp90 inhibitory and antifungal effects. In the presence of 2',4'-DHC (8 microg/mL), radial growth...
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Case of seropositive allergic bronchopulmonary aspergillosis in a 10-year-old girl without previously documented asthma

Shin JE, Shim JW, Kim DS, Jung HL, Park MS, Shim JY

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was...
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Expression and Activity of Catalases Is Differentially Affected by GpaA (Ga) and FlbA (Regulator of G Protein Signaling) in Aspergillus fumigatus

Shin KS, Yu JH

Vegetative growth signaling of the opportunistic human pathogenic fungus Aspergillus fumigatus is mediated by GpaA (Galpha). FlbA is a regulator of G protein signaling, which attenuates GpaA-mediated growth signaling in...
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Two Different Cases of Stenotrophomonas Maltophilia Endophthalmitis after Cataract Surgery

Jung JW, Kang HK, Chin HS

PURPOSE: To report 2 different cases of postoperative endophthalmitis caused by Stenotrophomonas maltophilia after cataract surgery. CASE SUMMARY: A 73-year-old male with diabetes mellitus developed severe pain in the right eye...
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Sexual Life Cycle of Aspergillus fumigatus

Kwon-Chung KJ, Sugui JA

  • KMID: 1449525
  • Korean J Med Mycol.
  • 2011 Sep;16(3):81-85.
Aspergillus fumigatus, the major etiologic agent of invasive aspergillosis, is a bipolar heterothallic species that produces teleomorphs belonging to the genus Neosartorya. Unlike A. fischeri and other sexual species phylogenetically...
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A Protective Mechanism in Lungs of Rats Experimentally Infected with Aspergillus fumigatus

Mahmoud YA, Al-Ghamdi , Abd El-Zaher EHF

  • KMID: 2312609
  • Mycobiology.
  • 2011 Mar;39(1):40-44.
Aspergillus fumigatus is associated with invasive disease aspergillosis in immunocompromised individuals. The major aim of this study was to investigate the biochemical and immunological responses of male Wistar rats against...
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Aspergillus fumigatus Scleritis Associated with Monoclonal Gammopathy of Undetermined Significance

Jo DH, Oh JY, Kim MK, Heo JW, Lee JH, Wee WR

A 68-year-old woman presented with pain in her left eye. Necrosis with calcium plaques was observed on the medial part of the sclera. Aspergillus fumigatus was isolated from the culture...
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Prophylactic and Therapeutic Potential of Asp f1 Epitopes in Naive and Sensitized BALB/c Mice

Chaudhary , Mahajan L, Madan T, Kumar A, Raghava GP, Katti SB, Haq W, Sarma PU

BACKGROUND: The present study examines a hypothesis that short allergen-derived peptides may shift an Aspergillus fumigatus (Afu-) specific TH2 response towards a protective TH1. Five overlapping peptides (P1-P5) derived from...
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A case of infective endocarditis caused by Aspergillus fumigatus in a liver transplant recipient

Hong KW, Lee JA, Park HW, Kwon HL, Cho SJ, Kim JS, Eom JS

  • KMID: 2256174
  • Korean J Med.
  • 2008 Jul;75(1):115-118.
It is known that the incidence of fungal endocarditis is increasing as the precipitating factors, such as organ transplantation, use of immunosuppressive agents, previous cardiac surgery, AIDS, chemotherapy, and long-term...
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A Case of Septic Hip Arthritis Caused by Aspergillus fumigatus in a Liver Transplant Recipient

Kim T, Lee SR, Cho OH, Park KH, Oh R, Lee SO, Kim YS, Woo JH, Kim MN, Choi SH

Septic arthritis is an uncommon finding of invasive Aspergillosis. It can be caused by direct inoculation, post-surgical infection, and hematogenous spread. Articular aspergillosis often involves the knee. A 49-year-old man...
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Antifungal Activity of Lactic Acid Bacteria Isolated from Kimchi Against Aspergillus fumigatus

Kim JD

  • KMID: 2312471
  • Mycobiology.
  • 2005 Dec;33(4):210-214.
More than 120 isolates of lactic acid bacteria obtained from Kimchi was screened for antifungal activity against Aspergillus fumigatus. Approximately 10% of the isolates showed inhibitory activity and only 4.16%...
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