Korean J Fam Med.  2009 Jan;30(1):15-22. 10.4082/kjfm.2009.30.1.15.

Insulin-like Growth Factor 1 Level and Its Relating Factor in Korean Healthy Adults

• Choi HK
• Kong MH
• Ahn BH
• Kim SM
• Lee DJ
• Kim KM

• KMID: 2304552
• DOI: http://doi.org/10.4082/kjfm.2009.30.1.15

Abstract

BACKGROUND: The concern about growth hormone, used for treatment of growth hormone deficiency, wasting diseases, is increasing recently. There is much to be desired about the study for the reference range of insulin-like growth factor-1 (IGF-1) of Korean healthy adults, because there was a lack of studies of IGF-1 level. The authors investigated the concentration of IGF-1 according to age groups, and its correlation factors in healthy adults in Korea.
METHODS
The subjects were 10,681 Korean healthy adults (5,263 females, 5,418 males) aged over 20 years, who visited the Department of Family Practice and Community Health in a university hospital from March 1998 to December 2003. We excluded the subjects with DM, liver diseases, renal diseases, thyroid diseases, and cancer. We measured the serum IGF-1, fasting glucose, lipid profile, serum albumin, protein, waist circumference, hip circumference, and body mass index.
RESULTS
IGF-1 level showed gender difference (184.6 +/- 86.3 ng/mL for men, 178.6 +/- 91.8 ng/mL for women) and decreased significantly with age. Age was the most reliable correlation factor with IGF-1 (R: -0.325 for men, R: -0.463 for women). After adjusting fot age and weight, IGF-1 showed correlations with total protein, albumin, creatinine, triglycerides, and HDL cholesterol for men and height, waist circumference, body mass index, waist-hip ratio, systolic blood pressure, total protein, albumin, creatinine, triglycerides, and HDL cholesterol for women.
CONCLUSION
IGF-1 concentration decreased with age over 20 years old. It showed the highest correlation with age in both gender.

Keyword

Insulin-Like Growth Factor-1; Age; Sex

MeSH Terms

Adult
Aged
Blood Pressure
Body Mass Index
Cholesterol, HDL
Creatinine
Family Practice
Fasting
Female
Glucose
Growth Hormone
Hip
Humans
Insulin-Like Growth Factor I
Korea
Liver Diseases
Male
Reference Values
Serum Albumin
Thyroid Diseases
Triglycerides
Waist Circumference
Waist-Hip Ratio
Wasting Syndrome
Cholesterol, HDL
Creatinine
Glucose
Growth Hormone
Insulin-Like Growth Factor I
Serum Albumin
Triglycerides