Korean J Fam Med.  2009 Feb;30(2):98-105. 10.4082/kjfm.2009.30.2.98.

Metabolic Syndrome and the Risk for Chronic Kidney Disease among Korean Women

• Chae SK
• Lee JS
• Chun JH
• Park HS

• KMID: 2304545
• DOI: http://doi.org/10.4082/kjfm.2009.30.2.98

Abstract

BACKGROUND: Metabolic syndrome (MetS), characterized by abdominal obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, high blood pressure, and high fasting glucose level, is a common risk factor for cardiovascular diseases and associated complications. We examined the relationship between the metabolic syndrome and risk of chronic kidney disease (CKD) in Korean women.
METHODS
We used data from 10,170 women, aged 30-89 years, who had visited a health examination center at a tertiary care hospital in 2006. The data were studied cross-sectionally. MetS was identified using the modified criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). CKD was defined as an estimated GFR < 60 ml/min per 1.73 m2. The multivariable-adjusted (adjustment for age, education, body mass index (BMI), alcohol drinking, smoking, previous coronary heart disease, menopauses and physical inactivity) odds ratio of CKD (95% CI) associated with each component of the metabolic syndrome was calculated using the logistic regression models.
RESULTS
A total of 1,039 participants have MetS. The multivariable-adjusted odds ratios (OR) of CKD in participants with MetS, hypertriglyceridemia and high blood pressure compared with participants without such factors were 2.68 (95% CI, 1.77-4.06), 1.96 (95% CI, 1.34-2.88), and 2.00 (95% CI, 1.38-2.89). Compared with the participants with no MetS traits, those with one, two, equal to or more than three traits of MetS had OR of CKD of 1.24 (95% CI, 0.75-2.06), 1.56 (95% CI, 0.89-2.75), and 2.18 (95% CI, 1.21-3.93), respectively.
CONCLUSION
We found that Korean women with MetS had an increased risk for developing CKD. Finally, earlier identification and management of MetS might improve patient health and prevent progression of CKD.

Keyword

Metabolic Syndrome; Chronic Kidney Disease; Glomerular Filtration Rate

MeSH Terms

Adult
Aged
Alcohol Drinking
Body Mass Index
Cardiovascular Diseases
Cholesterol
Coronary Disease
Fasting
Female
Glomerular Filtration Rate
Glucose
Humans
Hypertension
Hypertriglyceridemia
Lipoproteins
Logistic Models
Obesity, Abdominal
Odds Ratio
Renal Insufficiency, Chronic
Risk Factors
Smoke
Smoking
Tertiary Healthcare
Cholesterol
Glucose
Lipoproteins
Smoke