Korean J Dermatol.  1991 Jun;29(3):377-383.

Detection of human papillomavirus DNA in genital warts showing atypical manifestations

• Choi JH
• Sung KJ
• Lee MW
• Koh JK
• Yu HJ
• Lee SC
• Park KC

Abstract

In situ hybridization using radioactively labeled(S) and nonradioactively labeled probes was performed to detect HPV DNA and to compare the sensitivity of two probes in 17 patients with genital warts showing atypical manifestations. HPV 6/ll was found in 100%(3/3) of the flat type, 50%(2/4) of the pigmented type and 66.7%(2/3) of the flat and pigmented type (except bowenoid papulosis) and 66.7%(2/3) of the large extensive type. However HPV 16/18 was not found at all. In bowenaid papulosis, HPV 16/18 was detected in 25% (1/4) of the cases but HPV 6/11 was negative in all cases. There was no significant difference between the sensitivity of radioactiue and nonradioactive probes. HPV 6/11 was positive in the giant condyloma acuminata complicated with squamous cell carcinoma.

Keyword

Atypical genital warts; HPV; In situ hybridization

MeSH Terms

Carcinoma, Squamous Cell
Condylomata Acuminata*
DNA*
Humans*
In Situ Hybridization
DNA