Korean J Dermatol.  1992 Aug;30(4):446-453.

Immunohistochemical study on sweat gland tumors with monoclonal antibodies against S-100 subunits

• Sung KJ
• Cho KH
• Suh HS
• Choi JH
• Koh JK

Abstract

S-100 protein is a mixture of three proteins, that is, S-100 ao(aa), S-100 a(ab) and, S- 100 b(bb). Twenty-two case, of sweat gland tumors were stained with immunoperoxidase technique (ABC method) for the presence of S-100a and b-subunit. Four syringomas, four eccrine poromas, two eccrine porocarcinomas, two ecerine spirdeiomas, one papillary eccrine adenoma, three clear cell hidradenomas, three mixed tumr rs of the skin, two papillary syringocystadenomas, and one cylindroma were included. All specimens were formalin-fixed and paraffin-embedded. The results were as follows : 1) The staining patterns of anti-S-100a and b-protein antibodies we e simillar to those of anti-S-100 protein antibody except in eccrine poroma and porocare nomal. 2) In eccrine poroma and porocarcinoma, scattered S-100-positive dendritic cells within tumor cell nests were stained by S-100-protein antibody (3/6), but not by anti-S-100a protein antibody. S-100p is present in normal Langerhans cells. Therefore this finding suggests that these cells niay be Langerhans cells

Keyword

Immunohistochemical staining; S-100a; S-100p; Sweat gland tumor; Langerhans cell

MeSH Terms

Acrospiroma
Adenoma
Antibodies
Antibodies, Monoclonal*
Carcinoma, Adenoid Cystic
Dendritic Cells
Eccrine Porocarcinoma
Immunoenzyme Techniques
Langerhans Cells
Poroma
S100 Proteins
Skin
Sweat Glands*
Sweat*
Syringoma
Antibodies
Antibodies, Monoclonal
S100 Proteins