Korean J Dermatol.  2002 Aug;40(8):1007-1009.

A Case of Self-healing Langerhans Cell Histiocytosis

• Jeong KB
• Kim HC
• Shin DH
• Choi JS
• Kim KH
• Kim DS

Abstract

Langerhans cell histiocytosis is a proliferative disease in which Langerhans cells accumulate in various body sites and cause damage to the affected organs. We report a 7-month-old infant who had only cutaneous lesions and healed spontaneously without treatment. There were rice grain to corn sized erythematous papules and crusted lesions in the chest, abdomen, and back for 2 months. The histologic finding of the lesion showed that the dyscohesive infiltrate, predominantly of histiocytes, were present and extravasated erythrocytes and eosinophils were also found in edematous papillary dermis. Careful examination showed histiocytes with coffee bean or kidney-shaped nucleus which was positive for S-100 protein. The infant had no systemic involvement, and healed spontaneously after 1 month without relapse.

Keyword

Langerhans cell histiocytosis; Self-healing

MeSH Terms

Abdomen
Edible Grain
Coffee
Dermis
Eosinophils
Erythrocytes
Histiocytes
Histiocytosis, Langerhans-Cell*
Humans
Infant
Langerhans Cells
Recurrence
S100 Proteins
Thorax
Zea mays
Coffee
S100 Proteins