Korean J Dermatol.  2008 Apr;46(4):494-498.

A Case of Paraneoplastic Pemphigus Presenting with Generalized Exfoliative Dermatitis

Affiliations
  • 1Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. jeebumlee@hanmail.net
  • 2Mijiye Skin Clinics Gwangju, Korea.

Abstract

We describe a 56-year-old Korean man with paraneoplastic pemphigus (PNP) associated with persistent generalized exfoliative dermatitis (GED). He developed multiple scattered flaccid bullae on the erythematous base with scales over his face, upper trunk and extremities, with mucosal involvement for 4 months. Due to myasthenia gravis he also suffered from ptosis, general weakness, and weight loss of 10 kg for a month. A computed tomography and histopathological examination of the chest revealed a mass in the anterior mediastinum which was confirmed as thymoma. During the course of disease, his erythematous patch with crust lesions became confluent, and then GED developed. After total thymectomy, GED waxed and waned for 2-years and eventually disappeared. Herein, we report an interesting case of PNP associated with persistent GED for at least 2 years, even though the patient had been treated with surgery and medication.

Keyword

Generalized exfoliative dermatitis; Myasthenia gravis; Paraneoplastic pemphigus; Thymoma

MeSH Terms

Blister
Dermatitis, Exfoliative
Extremities
Humans
Mediastinum
Middle Aged
Myasthenia Gravis
Pemphigus
Thorax
Thymectomy
Thymoma
Weight Loss
Weights and Measures
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