Korean J Dermatol.  2010 Jul;48(7):594-596.

Double Primary Squamous Cell Carcinoma on a Psoriasis Patient

• Lim HS
• Lim SY

Abstract

Non-melanoma skin cancer in a psoriasis patient is known to be associated with the treatments for psoriasis such as long-term use of PUVA and cyclosporine rather than the psoriasis itself. We report here on a case of double primary squamous cell carcinoma and acanthosis on a patient who had no history of oral steroid and cyclosporine management. A 44 years old male patient presented for ulcerative skin lesion on both soles. He underwent an operation of wide excision and reconstruction for two separated malignant lesions with using a free flap and skin graft, respectively. Another skin lesion was found on his finger during the follow-up period and excisional biopsy was performed. No evidence of recurrence or metastasis of the squamous carcinoma was found during 2 years follow-up. The excisional biopsy done on his finger was revealed to be acanthosis and no further surgical intervention was needed. This case has an implication that physicians should consider the possibility of multiple skin cancers in a psoriasis patient irrespective of having received immunosuppression therapy, and physicians should try to make an early diagnosis to minimize the patient's morbidity and mortality.

Keyword

Immunosuppression; Psoriasis; Squamous cell carcinoma

MeSH Terms

Biopsy
Carcinoma, Squamous Cell
Cyclosporine
Early Diagnosis
Fingers
Follow-Up Studies
Free Tissue Flaps
Humans
Immunosuppression
Male
Neoplasm Metastasis
Psoriasis
Recurrence
Skin
Skin Neoplasms
Transplants
Ulcer
Cyclosporine