Korean J Dermatol.  2010 Aug;48(8):725-728.

Kikuchi's Disease Presented with Cutaneous Lesion Showing Diffuse Erythematous Maculopatches

• Park SH
• Noh TW
• Kang YS
• Lee UH
• Park HS
• Jang SJ

Abstract

Kikuchi's disease, or histiocytic necrotizing lymphadenopathy is an idiopathic, benign self-limiting lymphadenitis usually affecting young women. Cutaneous findings in Kikuchi's disease have been reported in 16~40% of cases. A 29-year-old woman presented with pruritic diffuse erythematous maculopatches on whole body accompanied by long-lasting fever and cervical lymphadenopathy. Skin biopsy showed vacuolar degeneration of the basal layer and dermal infiltration of CD68-positive histiocytes. Lymph node fine needle aspiration specimens showed abundant lymphocytes, histiocytes, karyorrhectic debris without neutrophils, consistent with Kikuchi's disease. We present a case of Kikuchi's disease showing generalized skin eruption with a review of literature that describes patterns of skin involvement.

Keyword

Histiocytic necrotizing lymphadenopathy; Kikuchi's disease

MeSH Terms

Adult
Biopsy
Biopsy, Fine-Needle
Female
Fever
Histiocytes
Histiocytic Necrotizing Lymphadenitis
Humans
Lymph Nodes
Lymphadenitis
Lymphatic Diseases
Lymphocytes
Neutrophils
Skin