Korean J Dermatol.  2012 Feb;50(2):123-129.

Comparative Study of Intralesional Triamcinolone Alone or in Combination with 5-Fluorouracil for the Treatment of Keloid and Hypertrophic Scars

• Yoo CS
• Kim CW
• Kim SS

Abstract

BACKGROUND
Keloids and hypertrophic scars may complicate wound healing secondary to trauma or surgery. They are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems for patients.
OBJECTIVE
The purpose of this study was to evaluate the efficacy of using a 5-FU (Fluorouracil)/Triamcinolone acetonide (TCN) mixture to treat keloids and hypertrophic scars. Further, the results were compared via TCN alone.
METHODS
Patient chart from 2007 to 2011 were reviewed. Patients were stratified into 2 groups: (1) intralesional injection of TCN 0.1 ml (40 mg/ml) mixed with 5-FU 0.9 ml (50 mg/ml), every 2 weeks; (2) intralesional injection of TCN (20 mg/ml), every 2 weeks. Lesions were assessed for height, erythema, pliability, pruritus, pain/tenderness, patient-self assessment and side effects at baseline (initiation of treatment) and at weeks 2, 4, 6.
RESULTS
There has been 23 patients (43 lesions) that completed the study. At the 2, 4, 6 week visits, both groups showed an acceptable improvement in all nearly parameter., However, in comparison between the groups, there was no statistically significant differences (p>0.05). Complications such as injection pain and hyperpigmentation were seen in both treatment groups.
CONCLUSION
The overall efficacy of 5-FU/TCN mixture was comparable with TCN alone.

Keyword

5-Fluorouracil; Hypertrophic scar; Keloid; Triamcinolone acetonide

MeSH Terms

Cicatrix, Hypertrophic
Collagen
Cosmetics
Erythema
Fluorouracil
Humans
Hyperpigmentation
Injections, Intralesional
Keloid
Pliability
Pruritus
Triamcinolone
Triamcinolone Acetonide
Wound Healing
Collagen
Cosmetics
Fluorouracil
Triamcinolone
Triamcinolone Acetonide