Korean J Dermatol.  2012 Aug;50(8):742-746.

A Case of Dermatomyositis with Acute Interstitial Pneumonitis Manifested as Antisynthetase Syndrome

• Son HH
• Jung SW
• Sim HS
• Lee SK

Abstract

Dermatomyositis is a systemic inflammatory disease affecting the skin, skeletal muscle, and occasionally, other organs, such as the lung. Interstitial lung disease (ILD) is a serious lung complication, which can occur in patients with dermatomyositis. It affects the prognosis of the disease and requires a more aggressive therapeutic approach. Interstitial lung disease (ILD) may be associated with systemic inflammatory disorders and autoantibody production. In particular, anti Jo-1 antibody has long been recognized as an important predictive factor in systemic manifestations of ILD in dermatomyositis. We report here a case of a 42 year old woman with cutaneous lesions typical of dermatomyositis, showing clinical features of antisynthetase syndrome, which showed rapid progression to acute respiratory distress syndrome.

Keyword

Antisynthetase syndrome; Dermatomyositis; Interstitial lung disease

MeSH Terms

Antibodies, Antinuclear
Dermatomyositis
Female
Humans
Lung
Lung Diseases, Interstitial
Muscle, Skeletal
Myositis
Prognosis
Respiratory Distress Syndrome, Adult
Skin
Antibodies, Antinuclear
Myositis