Korean J Clin Pathol.  1998 Dec;18(4):525-528.

A Case Report of t(8;22) with Additional Chromosomal Defects in Bone Marrow Involvement of B Cell Type Diffuse Large Cell Lymphoma

• Lee KH
• Lee YK
• Park JY
• Jeon HB
• Ahn JS
• Lee JA
• Park YS
• Cho HC

Abstract

The t(8;14)(q24;q32) translocation or its variants, t(2;8)(p12;q24) and t(8;22)(q24;q32) are classically seen in Burkitt's lymphoma, but are also found in diffuse large cell lymphoma (DLCL). Burkitt's lymphoma is very rare in Korea and t(8;14) or its variants have not been reported. We report a case of DLCL (B-cell type) with t(8;22) and additional chromosomal abnormalities. The patient, 45-year-old male, complained intermittent abdominal pain. The histologic examination of sigmoid colon revealed DLCL. Lymphoma cells were counted about 58.8% of all nucleated cells in bone marrow aspiration and showed surface membrane immunoglobulin positivity. Chromosome study of bone marrow aspiration was done using high resolution banding technique. The karyotype was 47,XY,+1,del(6)(q21),t(8;22)(q24;q11),del(13)(q31),der(14)t(1;14)(q23;q32)?, del(17)(p11) in all of the nineteen metaphases which were analyzed. Although he was treated by chemotherapy and radiotherapy, lymphoma cells were increased in peripheral blood and he expired.

Keyword

t(8;22); Diffuse large cell lymphoma; Chromosome study

MeSH Terms

Abdominal Pain
Bone Marrow*
Burkitt Lymphoma
Chromosome Aberrations
Colon, Sigmoid
Drug Therapy
Humans
Immunoglobulins
Karyotype
Korea
Lymphoma
Lymphoma, Large B-Cell, Diffuse*
Male
Membranes
Metaphase
Middle Aged
Radiotherapy
Immunoglobulins