Korean J Blood Transfus.  2005 Dec;16(2):240-245.

The First Case of Febrile Transfusion Reaction Caused by Anti-HNA-1b Antibody in Korea

• Han TH
• Kim WS
• Han KS

Abstract

Febrile nonhemolytic transfusion reaction (FNHTR) is one of the most common adverse reactions to the transfusion of blood products. It is caused by antigen-antibody reactions between patient's plasma and transfused cellular components (or the reverse) or bioactive substances such as cytokines generated by leukocytes during storage of cellular blood components. Most of the antibodies involved in FNHTR are anti-HLA antibodies. However, platelet-specific antibodies and rarely granulocyte-specific antibodies may be involved in FNHTR, We found a granulocyte antibody from a 53-year-old male with FNHTR for the first time in Korea. Fever developed during transfusion of a unit of packed RBC after partial cystectomy, and subsided after the adminstration of acetaminophen. The hemolytic transfusion reaction and sepsis were excluded after investigations. Mixed passive hemagglutination test revealed that the patient had antibody against human neutrophil antigen-1b (HNA-1b), and granulocyte antigen genotyping showed granulocyte antigen mismatches between the patient (HNA-1a homozygote) and the unit of transfused RBC (HNA-1a/HNA-1b heterozygote).

Keyword

Febrile nonhemolytic transfusion reaction; Granulocyte antibody; Anti-HNA-1b

MeSH Terms

Acetaminophen
Antibodies
Antigen-Antibody Reactions
Blood Group Incompatibility*
Cystectomy
Cytokines
Fever
Granulocytes
Hemagglutination Tests
Humans
Korea*
Leukocytes
Male
Middle Aged
Neutrophils
Plasma
Sepsis
Acetaminophen
Antibodies
Cytokines