Korean J Blood Transfus.  2005 Dec;16(2):209-217.

Alleles for Associated with Fy(a), Fy(b), Fy(x) and Fy Antigens in a Korean Population

• Park KU
• Jeon AR
• Heo SR
• Song J
• Han KS

Abstract

BACKGROUND: In the Duffy blood group system (Fy(a), Fy(b), Fy(x), and Fy antigens), Fy(x) antigen is associated with weak Fy(b) while Fy antigen means the null phenotype Fy (a-b-). Fyx antigen and Fy antigen result from the polymorphisms of Fy125 allele. This report assessed the allele frequency and genotype frequency of Fy(a), Fy(b), Fy(x), and Fy antigens in Koreans.
METHODS
We performed a study of the followings on 253 visitors to the health promotion center of Seoul National University Bundang Hospital: PCR-RFLP and PCR-SSP for the detection of Duffy 125G > A and -33T > C; PCR-SSP for the detection of Duffy 265C > T and 298G > A.
RESULTS
The results of PCR-RFLP and PCR-SSP were consistent with each other in a total of 253 subjects. Allele frequency was as follows: Fy 92.3%, Fy(125) 6.1%, and fy(125/265) 1.6%. The fy(125/265) allele was newly observed. Fy(125/298), fy(125/265/298), and fy(-33/125) alleles were not detected in Koreans. The distribution of Duffy phenotypes in Koreans was as follows: Fy (a+b-) 88.1%, Fy (a-b+) 0.4%, Fy (a+b+) 11.5%, and Fy (a-b-) 0.0%. Fy (a+) was 99.6% and Fy (b+) was 11.9%.
CONCLUSION
In our study for Duffy polymorphisms, the frequency of Fy allele was very high. The frequency was similar to those of other Asian populations, but different from those of Caucasians. The fy(125/265) allele, which was associated with Fy(x) antigen, was newly detected in Koreans.

Keyword

Duffy blood group; Fy(x); Polymerase chain reaction; Genotype; Phenotype; Allele

MeSH Terms

Alleles*
Asian Continental Ancestry Group
Duffy Blood-Group System
Gene Frequency
Genotype
Health Promotion
Humans
Phenotype
Polymerase Chain Reaction
Seoul
Duffy Blood-Group System