Korean J Biol Psychiatry.  2008 Nov;15(4):303-309.

Association of the 5-HT5A Receptor Gene Polymorphisms and Citalopram Response in Korean Patients with Major Depressive Disorder

• Shim JH
• Paik JW
• Oh JW
• Kang RH
• Lee HY
• Lee MS

Abstract

OBJECTIVES
Some reports have suggested that 5-HT5A polymorphism allelic association was associated with depression, however, there has been no report about relationship between the 5-HT5A gene and antidepressant response. We conducted the association study of the 5-HT5A receptor gene polymorphisms (-19G/C,12A/T) and response to citalopram in Korean patients with major depressive disorder(MDD).
METHODS
A total of 106 patients with major depressive disorder were included in this study. The patient's symptoms were measured by 21-item Hamilton Depression Rating Scale(HAMD) at baseline, week 1, week 2, week 4 and week 8 during citalopram treatment. A Responder to citalopram was defined by 50% reduction of total HAMD scores. To analyze genetic polymorphisms, a polymerase chain reaction based method was used.
RESULTS
At week 8, responders were 62, non-responders were 44. No significant differences of genotypes or allelic association in 19G/C and 12A/T polymorphisms were observed between responsive and non-responsive patients.
CONCLUSION
These results do not support the hypothesis that this polymorphism of the HT5A receptor gene is involved in the therapeutic response to citalopram.

Keyword

Depression; 5HT5A receptor; Polymorphism; Citalopram; Pharmacogenetics

MeSH Terms

Citalopram
Depression
Depressive Disorder, Major
Genotype
Humans
Pharmacogenetics
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Serotonin
Citalopram
Receptors, Serotonin