Korean J Biol Psychiatry.
2008 Nov;15(4):254-264.
Neural Substrates of Fear Based on Animal and Human Studies
- Affiliations
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- 1Department of Bio and Brain Engineering, KAIST, Daejeon, Korea.
- 2Department of Psychology, Graduate school, Sungshin Women's University, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. alberto@catholic.ac.kr
Abstract
OBJECTIVES
The neural substrate of fear is thought to be highly conserved among species including human. The purpose of this review was to address the neural substrates of fear based on recent findings obtained from animal and human studies.
METHODS
Recent studies on brain regions related to fear, particularly fear conditioning in rodents and humans, were extensively reviewed.
RESULTS
This paper suggests high consistency in anatomical structure and physiological mechanisms for fear perception, response, learning and modulation in animals and humans.
CONCLUSIONS
Fear is manifested and modulated by well conserved neural circuits among species interconnected with the amygdala, such as the hippocampus and the ventromedial prefrontal cortex. Further research is required to incorporate findings from animal studies into a better understanding of neural circuitry of fear in human in a translational approach.
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