Korean J Biol Psychiatry.
2015 May;22(2):34-39. 10.0000/kjbp.2015.22.2.34.
Neuroglia and Mood Disorder
- Affiliations
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- 1Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, Korea. iybihwc@naver.com
- 2Paik Institute for Clinical Research, Inje University, Busan, Korea.
- 3Department of Health Science and Technology, Graduate School of Inje University, Busan, Korea.
- KMID: 2299825
- DOI: http://doi.org/10.0000/kjbp.2015.22.2.34
Abstract
- Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. A serious problem such as suicide is commonly occurring in the patients with depression. Till now, the monoamine hypothesis has been the most popular theory of pathogenesis for depression. However, the more specific pathophysiology of depression and cellular molecular mechanism underlying action of commercial antidepressants have not been clearly defined. Several recent studies demonstrated that glial cells, especially astrocytes, are a promising answer to the pathophysiology of depression. In this article, current understanding of biology and molecular mechanisms of glial cells in the pathology of mood disorder and new research on the pathophysiology of depression will be discussed.
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