Korean J Anesthesiol.  2010 Apr;58(4):391-395. 10.4097/kjae.2010.58.4.391.

Anaphylaxis with angioedema by rocuronium during induction of general anesthesia: A case report

• Jeong WJ
• Kim WY
• Son JH
• Lee YS
• Kim JH
• Park YC

• KMID: 2299339
• DOI: http://doi.org/10.4097/kjae.2010.58.4.391

Abstract

Perioperative anaphylaxis is characterized by severe respiratory and cardiovascular manifestations. Correct management of anaphylaxis during anaesthesia requires a multidisciplinary approach with prompt recognition and treatment of the acute event by the attending anesthesiologist. A 34-year-old woman was scheduled to undergo endo venous laser therapy of varicose veins. She had no history of allergies and had never undergone general anesthesia. General anesthesia was induced with propofol and rocuronium bromide. Approximately three minutes after rocuronium administration, hypotension and tachycardia developed and angioedema around the eyelids and skin rashes and urticaria appeared. The patient received ephedrine and hydrocortisone with hydration. After achieving stable vital signs and symptom relief, surgery was performed without complications. A postoperative skin dermal test performed to identify the agent responsible revealed a positive skin test for rocuronium.

Keyword

Anaphylaxis; Angioedema; Intradermal skin test; Rocuronium

MeSH Terms

Adult
Anaphylaxis
Androstanols
Anesthesia, General
Angioedema
Ephedrine
Exanthema
Eyelids
Female
Humans
Hydrocortisone
Hypersensitivity
Hypotension
Laser Therapy
Propofol
Skin
Skin Tests
Tachycardia
Urticaria
Varicose Veins
Vital Signs
Androstanols
Ephedrine
Hydrocortisone
Propofol