Korean J Anesthesiol.  2008 Aug;55(2):166-170. 10.4097/kjae.2008.55.2.166.

The effects of amounts of intraoperative intravenous fluid administration on postoperative nausea and vomiting during gynecological surgery

• Yoon JS
• Kim KM
• Kim YH

• KMID: 2299198
• DOI: http://doi.org/10.4097/kjae.2008.55.2.166

Abstract

BACKGROUND
Perioperative fluid deficits is known to induce the intestinal ischemia and release the emetogenic factors like serotonin. Many studies have reported that there is a close association between the amount of perioperative fluid administration and the incidence of postoperative nausea and vomiting (PONV). In this study, we examined whether amounts of intraoperative intravenous fluid administration would be related with the incidence of PONV in patients scheduled for gynecological surgery.
METHODS
One hundred twenty gynecological patients with ASA I-II were randomized to receive either large (18 ml/kg/hr) or small (6 ml/kg/hr) volume infusion of lactated Ringer's solution intraoperatively. The incidence of PONV, severity of pain, and need for supplemental antiemetic and analgesic therapy were assessed by a blinded investigator at 0-2, 2-6, and 6-24 h postoperatively.
RESULTS
There were no significant differences between the two groups in the severity of pain and amounts of rescue antiemetics and rescue analgesics administration at any given time. There were no differences between the two groups regarding the incidence of PONV at 0-2, 2-6, and 6-24 h, postoperatively.
CONCLUSIONS
Intraoperative large volume infusion of lactated Ringer's solution was ineffective in reducing the incidence of PONV in patients scheduled for gynecological surgery during the postoperative period.

Keyword

fluid; gynecological surgery; PONV

MeSH Terms

Analgesics
Antiemetics
Female
Gynecologic Surgical Procedures
Humans
Incidence
Ischemia
Isotonic Solutions
Postoperative Nausea and Vomiting
Postoperative Period
Research Personnel
Serotonin
Analgesics
Antiemetics
Isotonic Solutions
Serotonin